PlainPill
PeptideMemoryFocusMood

Dihexa

People mainly take Dihexa for memory, focus, mood. Based on 35 first-hand reports and 1 meta-analyses & systematic reviews in the medical literature. Ranked #438 of 1,974 overall.

Compare with…Alternatives for memory
28
User score
Mostly positive
20% positive3% mixed0% negative77% unclear

Of reports that state an outcome, 87% are positive.

Clinical research
BModerate research base
1
meta-analyses
0
RCTs
17
papers
High-risk compound. Peptides are not approved as supplements, carry serious and sometimes irreversible risks, are banned in competitive sport and may be restricted where you live. Nothing here is a recommendation to use it.

What Dihexa does, according to users

Of the people who reported each effect, the share who said it got better.

Memory100% of 6Focus100% of 5Mood100% of 3
3 more with fewer than 3 reports
Recovery100% of 1Sleep100% of 1Energy100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

Neurosci Biobehav Rev · 2018 · Meta-analysis / systematic review
Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies

Conclusion: Studies of cognitive impairment show salutary effects of acute administration of Ang IV and its analogs, as well as AT4R activation. Brain RAS peptides appear most effective administered intracerebroventricularly, close to the time of learning acquisition or retention testing. Ang-(1-7) shows anti-dementia qualities.

PubMed 29733881 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

0.5 mL (~8 mg)every other evening
1 g (purchased)as reported
15-30 mgevery 3-5 days for at most 5 weeks
500mg totalas reported

Reported side effects

How often each side effect came up across all reports.

vivid dreams ×2itching ×1cancer risk ×1cancer ×1autism-like symptoms ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Dihexa”
Source discussion ↗
“Another person applied Dihexa(which someone said is similar to ISRIB) dissolved in DSMO to their forearm.”
Source discussion ↗
“I think I may give Cerebrolysin and/or dihexa a try next.”
Source discussion ↗
“Dihexa looks pretty good. I'm part of a group buy for it. My grandfather has senile dementia and I'm looking forward to seeing whether it can help him. 10 million times BDNF power seems promising.”
Source discussion ↗
“Dihexa was an incredible experience; like a time-release NSI-189 without any of the annoying contraindications and energy fluctuations.”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate