PlainPill

What people actually say

1,817 first-hand quotes, shortened but never edited — each links to the original discussion.

AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
CoffeeMixed
“Many people report that quitting coffee improved or even cured their IBS, including me. I quit coffee about three years ago and I feel better without the caffeine rush.”
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CoffeeMixed
“So i quit coffee. First two days sucked. But now, everything is lighter, temporary and I am finding giggles in everyday items.”
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CoffeeMixed
“I have noticed that I respond better to a cup of black coffee as opposed to a 200 mg tablet of caffeine.”
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“I was very anxious and listless for a while and the substances that helped me the most were Pramiracetam + alpha GPC.”
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“have been using pram for a few days and wondering if I should switch to noopept. In terms of effect, felt a wee bit more motivated, def had headaches for a short while.”
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“By far the most potent nootropic I have tried. The biggest aspect that I have noticed is sense of well being and reduced anxiety. And one of the weirdest effects is I do not crave stimulants anymore.”
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“Pramiracetam has always reliably worked for me. I find my recall is improved...but it made me too focused and had a blunting effect on my emotions.”
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PhosphatidylserineMostly positive
“A supplement I have never seen on here that works great for me is Phosphatidylserine. Somehow awesome.”
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PhosphatidylserineMostly positive
“I have been taking this...and I have had great results...From my research, I found phosphatidylserine to be of little to no benefit on cognitive function.”
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PhosphatidylserineMostly positive
“Phosphatidylserine (8/10): ... it made a pretty big impact as far as stress reduction for me. I felt less physical anxiety in social situations...”
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PhosphatidylserineMostly positive
“within 10-15 minutes if I'm feeling more down to Earth and relaxed...Over the last three weeks, I have seldom had these nervous thought loops.”
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“I have an autoimmune condition that causes chronic pain and while it doesn’t eliminate the pain, I noticed an overall reduction in the intensity day to day.”
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“I’ve tried physical therapy, swimming, exercises, omega-3, turmeric, and other anti-inflammatory stuff—nothing seems to help.”
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“Whenever I add raw Turmeric & Ginger to my stack, I feel any existing brain fog disappear within 15 minutes... That's very unlikely that chewing on turmeric would affect you so strongly and so quickly.”
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“Turmeric and Magnesium make me feel like absolute shit if I take them before sunset.”
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SemaglutideMostly positive
“I've lost 35lbs since then and now I'm in the Healthy range on BMI. My IBSD has virtually disappeared.”
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SemaglutideMostly positive
“I tried ozempic at first. Made me really sick so I stopped.”
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SemaglutideMostly positive
“I recently cycled off Ozempic after 6 months. It did not agree with me...profund depression...profound depression(something I dont normally have an issue with).”
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SemaglutideMostly positive
“I’ve noticed since getting on the wegovy I have felt like I’ve been in a strange depression. I’m not explicitly suicidal but I feel nothing - no happiness, no love, no hope.”
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TianeptineMostly positive
“It has really improved the quality of my life, more than anything else I have taken.”
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TianeptineMostly positive
“it made my head foggy and made me more anxious. Noticed no improvement in mood.”
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TianeptineMostly positive
“I take 15mg 3x daily, and it keeps me out of depression and in a good mood. It also helps me focus in class more.”
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TianeptineMostly positive
“I was able to successfully quit using low doses of tianeptine. But be careful as that can be an even worse addiction.”
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CistancheMostly positive
“Cistanche extract increases my drive, energy and vigor. It makes me want to attack life. I get better sleep...My work ethic has improved. My memory. my attitude towards life. Every facet of my life has been altered in a positive meaningful way.”
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CistancheMostly positive
“Fucking hated it. After just a week on it my libido went non existent. It left me feeling numb, unmotivated and lazy.”
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CistancheMostly positive
“Increases energy, boosts my mood, makes me feel more chilled, better libido, I feel more confident.”
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CistancheMostly positive
“cistanche is the only thing I had to stop taking because it worked too well...cistanche is the only thing that made me horny all the time.”
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ALAMostly positive
“I also take alcar, alpha lipoic acid, choline, and pqq, but... there is some difference with these, but not as major as with CoQ10.”
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ALAMostly positive
“ALCAR+alpha lipoic acid works as well as Adderall. Actually, it's a bit better for me—it wears off more slowly and doesn't interfere with sleep the way Adderall does.”
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ALAMostly positive
“ALA fixed the issue almost instantly, so I usually don't take ALCAR without the ALA.”
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ALAMostly positive
“R-ALA - has shrunk keloids that I was told would never go away and helped with general over all MS body pain”
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PsilocybinMostly positive
“Mushrooms make me a better husband and a better human all around. Sometimes I don’t feel the urge to have sex while I’m on a dose, but I feel much more connected afterward. Low dose is definitely an aphrodisiac in my experience.”
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PsilocybinMostly positive
“doing shrooms helped a lot. I felt really peaceful...This slowly went away, and was gone the next day.”
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PsilocybinMostly positive
“I also micro dose psilocybin on and off and macro dose once in awhile. This definitely helps with my overall well-being and mood.”
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PsilocybinMostly positive
“The psilocybin just made my mind quieter and allowed me to focus on one thing at a time. Its also helped me just stay in a positive mood which helped my anxiety.”
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“St. John's Wort, Passion Flower, Hops, and Skullcap. My sleep improved with those.”
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“even the nootropics that some communities swear by did nothing for me (some that come to mind - racetams, tyrosine/NALT, NAC, methylated B vitamins...”
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“I dabbled with 5-HTP ... and St. John's Wort ... and found them to have some nice anti-anxiety / sedating effects.”
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“I am taking Saint John's Wort and Bacopa now to modulate my serotonin system, as well as trimethylglycine to help boost catecholamine production. That is helping a lot.”
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Lithium OrotateMostly positive
“The lithium is absolutely curbing my mania... My social anxiety is 100% gone when I take lithium orotate.”
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