What people actually say
1,817 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
CoffeeMixed
“Many people report that quitting coffee improved or even cured their IBS, including me. I quit coffee about three years ago and I feel better without the caffeine rush.”Source discussion ↗
CoffeeMixed
“So i quit coffee. First two days sucked. But now, everything is lighter, temporary and I am finding giggles in everyday items.”Source discussion ↗
CoffeeMixed
“I have noticed that I respond better to a cup of black coffee as opposed to a 200 mg tablet of caffeine.”Source discussion ↗
PramiracetamMixed
“I was very anxious and listless for a while and the substances that helped me the most were Pramiracetam + alpha GPC.”Source discussion ↗
PramiracetamMixed
“have been using pram for a few days and wondering if I should switch to noopept. In terms of effect, felt a wee bit more motivated, def had headaches for a short while.”Source discussion ↗
PramiracetamMixed
“By far the most potent nootropic I have tried. The biggest aspect that I have noticed is sense of well being and reduced anxiety. And one of the weirdest effects is I do not crave stimulants anymore.”Source discussion ↗
PramiracetamMixed
“Pramiracetam has always reliably worked for me. I find my recall is improved...but it made me too focused and had a blunting effect on my emotions.”Source discussion ↗
PhosphatidylserineMostly positive
“A supplement I have never seen on here that works great for me is Phosphatidylserine. Somehow awesome.”Source discussion ↗
PhosphatidylserineMostly positive
“I have been taking this...and I have had great results...From my research, I found phosphatidylserine to be of little to no benefit on cognitive function.”Source discussion ↗
PhosphatidylserineMostly positive
“Phosphatidylserine (8/10): ... it made a pretty big impact as far as stress reduction for me. I felt less physical anxiety in social situations...”Source discussion ↗
PhosphatidylserineMostly positive
“within 10-15 minutes if I'm feeling more down to Earth and relaxed...Over the last three weeks, I have seldom had these nervous thought loops.”Source discussion ↗
TurmericMixed
“I have an autoimmune condition that causes chronic pain and while it doesn’t eliminate the pain, I noticed an overall reduction in the intensity day to day.”Source discussion ↗
TurmericMixed
“I’ve tried physical therapy, swimming, exercises, omega-3, turmeric, and other anti-inflammatory stuff—nothing seems to help.”Source discussion ↗
TurmericMixed
“Whenever I add raw Turmeric & Ginger to my stack, I feel any existing brain fog disappear within 15 minutes... That's very unlikely that chewing on turmeric would affect you so strongly and so quickly.”Source discussion ↗
TurmericMixed
“Turmeric and Magnesium make me feel like absolute shit if I take them before sunset.”Source discussion ↗
SemaglutideMostly positive
“I've lost 35lbs since then and now I'm in the Healthy range on BMI. My IBSD has virtually disappeared.”Source discussion ↗
SemaglutideMostly positive
“I tried ozempic at first. Made me really sick so I stopped.”Source discussion ↗
SemaglutideMostly positive
“I recently cycled off Ozempic after 6 months. It did not agree with me...profund depression...profound depression(something I dont normally have an issue with).”Source discussion ↗
SemaglutideMostly positive
“I’ve noticed since getting on the wegovy I have felt like I’ve been in a strange depression. I’m not explicitly suicidal but I feel nothing - no happiness, no love, no hope.”Source discussion ↗
TianeptineMostly positive
“It has really improved the quality of my life, more than anything else I have taken.”Source discussion ↗
TianeptineMostly positive
“it made my head foggy and made me more anxious. Noticed no improvement in mood.”Source discussion ↗
TianeptineMostly positive
“I take 15mg 3x daily, and it keeps me out of depression and in a good mood. It also helps me focus in class more.”Source discussion ↗
TianeptineMostly positive
“I was able to successfully quit using low doses of tianeptine. But be careful as that can be an even worse addiction.”Source discussion ↗
CistancheMostly positive
“Cistanche extract increases my drive, energy and vigor. It makes me want to attack life. I get better sleep...My work ethic has improved. My memory. my attitude towards life. Every facet of my life has been altered in a positive meaningful way.”Source discussion ↗
CistancheMostly positive
“Fucking hated it. After just a week on it my libido went non existent. It left me feeling numb, unmotivated and lazy.”Source discussion ↗
CistancheMostly positive
“Increases energy, boosts my mood, makes me feel more chilled, better libido, I feel more confident.”Source discussion ↗
CistancheMostly positive
“cistanche is the only thing I had to stop taking because it worked too well...cistanche is the only thing that made me horny all the time.”Source discussion ↗
ALAMostly positive
“I also take alcar, alpha lipoic acid, choline, and pqq, but... there is some difference with these, but not as major as with CoQ10.”Source discussion ↗
ALAMostly positive
“ALCAR+alpha lipoic acid works as well as Adderall. Actually, it's a bit better for me—it wears off more slowly and doesn't interfere with sleep the way Adderall does.”Source discussion ↗
ALAMostly positive
“ALA fixed the issue almost instantly, so I usually don't take ALCAR without the ALA.”Source discussion ↗
ALAMostly positive
“R-ALA - has shrunk keloids that I was told would never go away and helped with general over all MS body pain”Source discussion ↗
PsilocybinMostly positive
“Mushrooms make me a better husband and a better human all around. Sometimes I don’t feel the urge to have sex while I’m on a dose, but I feel much more connected afterward. Low dose is definitely an aphrodisiac in my experience.”Source discussion ↗
PsilocybinMostly positive
“doing shrooms helped a lot. I felt really peaceful...This slowly went away, and was gone the next day.”Source discussion ↗
PsilocybinMostly positive
“I also micro dose psilocybin on and off and macro dose once in awhile. This definitely helps with my overall well-being and mood.”Source discussion ↗
PsilocybinMostly positive
“The psilocybin just made my mind quieter and allowed me to focus on one thing at a time. Its also helped me just stay in a positive mood which helped my anxiety.”Source discussion ↗
St. John's WortMixed
“St. John's Wort, Passion Flower, Hops, and Skullcap. My sleep improved with those.”Source discussion ↗
St. John's WortMixed
“even the nootropics that some communities swear by did nothing for me (some that come to mind - racetams, tyrosine/NALT, NAC, methylated B vitamins...”Source discussion ↗
St. John's WortMixed
“I dabbled with 5-HTP ... and St. John's Wort ... and found them to have some nice anti-anxiety / sedating effects.”Source discussion ↗
St. John's WortMixed
“I am taking Saint John's Wort and Bacopa now to modulate my serotonin system, as well as trimethylglycine to help boost catecholamine production. That is helping a lot.”Source discussion ↗
Lithium OrotateMostly positive
“The lithium is absolutely curbing my mania... My social anxiety is 100% gone when I take lithium orotate.”Source discussion ↗