St John's Wort
People mainly take St John's Wort for mood, anxiety, energy. Based on 89 first-hand reports. Ranked #361 of 1,974 overall.
32
User score
Mixed22% positive8% mixed18% negative52% unclear
Of reports that state an outcome, 46% are positive.
Clinical research
Research pending
What St John's Wort does, according to users
Of the people who reported each effect, the share who said it got better.
5 more with fewer than 3 reports
betterno changeworse
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
Research data for St John's Wort is being compiled.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
dailyas reported
above recommendeddaily
300 mg, 2.1 gas reported
morning and nightas reported
during the dayas reported
300-600 mg2x daily
Reported side effects
How often each side effect came up across all reports.
photosensitivity ×5serotonin syndrome ×2anxiety ×2eye problems ×2dissociation ×1eye damage ×1emotional numbness ×1apathy ×1
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“St johns wort is an SSRI / antidepressant, I became very dissociated from it and stopped very quickly because I cared about nothing anymore”
“I took myself off of lexapro, with a regimen of therapy, 5htp and st johns wort.”
“Adding in st Johns worst today”
“Saint John's Wort”
“St. John's Wort, Passion Flower, Hops, and Skullcap. My sleep improved with those.”
Other options for mood
Resistance Training
Lifestyle · 53 reports
100% report better mood
Mostly positive
Retatrutide
Peptide · 298 reports
69% report better mood
Mostly positiveBResearch: Moderate
Caffeine + L-Theanine
Supplement · 46 reports
100% report better mood
Mostly positive
Tirzepatide
Medication · 219 reports
76% report better mood
Mostly positiveAResearch: Strong
Creatine Monohydrate
Supplement · 139 reports
88% report better mood
Mostly positiveAResearch: Strong
Magnesium Malate
Supplement · 103 reports
100% report better mood
Mostly positiveDResearch: None
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate