What people actually say
345 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
SemaglutideMostly positive
“I've lost 35lbs since then and now I'm in the Healthy range on BMI. My IBSD has virtually disappeared.”Source discussion ↗
SemaglutideMostly positive
“I tried ozempic at first. Made me really sick so I stopped.”Source discussion ↗
SemaglutideMostly positive
“I recently cycled off Ozempic after 6 months. It did not agree with me...profund depression...profound depression(something I dont normally have an issue with).”Source discussion ↗
SemaglutideMostly positive
“I’ve noticed since getting on the wegovy I have felt like I’ve been in a strange depression. I’m not explicitly suicidal but I feel nothing - no happiness, no love, no hope.”Source discussion ↗
BerberineMixed
“I started berberine and inositol, and began having energy that I did not have before. Somehow, my recovery after working out wasn't as long either.”Source discussion ↗
BerberineMixed
“I find it makes a huge difference in keeping my BG stable. I've tested a dozen products/ingredients and berberine/lipo berberine/DHB all work fantastically.”Source discussion ↗
BerberineMixed
“I started berberine for high blood sugar but quickly noticed mood and energy enhancing effects from it. I've been taking 500 mg daily...I experienced the worst gastrointestinal issues ever, pure yellow diarrhea and smelly piss.”Source discussion ↗
BerberineMixed
“I take one after every meal and it really helps with not feeling like that since it does a whole bunch of beneficial things for blood sugar/insulin.”Source discussion ↗
PsilocybinMostly positive
“Mushrooms make me a better husband and a better human all around. Sometimes I don’t feel the urge to have sex while I’m on a dose, but I feel much more connected afterward. Low dose is definitely an aphrodisiac in my experience.”Source discussion ↗
PsilocybinMostly positive
“doing shrooms helped a lot. I felt really peaceful...This slowly went away, and was gone the next day.”Source discussion ↗
PsilocybinMostly positive
“I also micro dose psilocybin on and off and macro dose once in awhile. This definitely helps with my overall well-being and mood.”Source discussion ↗
PsilocybinMostly positive
“The psilocybin just made my mind quieter and allowed me to focus on one thing at a time. Its also helped me just stay in a positive mood which helped my anxiety.”Source discussion ↗
Black Seed OilMostly positive
“Black seed yes. I'm taking capsules of both strengths. I was hoping it would help with exczema/skin health. But so far it's mainly good for immunity, anxiety. Good all rounder but not sure I'll get it again.”Source discussion ↗
Black Seed OilMostly positive
“1.5 tsp a day and I'm finally enjoying music,video games and feel a genuine appreciation for being alive.”Source discussion ↗
Black Seed OilMostly positive
“i've tried CBD oil, black seed oil and NAC to help with the glutamate / gaba imbalance but I can't say any of these have significantly made my symptoms better.”Source discussion ↗
Black Seed OilMostly positive
“After I staryed taking black seed oil twice a day ive been feeling like a new person.”Source discussion ↗
Ginkgo BilobaMixed
“I've been able to notice a difference from taking (caffeine pills, Ginko Biloba pills, etc)”Source discussion ↗
Ginkgo BilobaMixed
“Im taking ginkgo biloba and L Citrulline and feel pretty good ,but the Ginkgo sometimes caused me headaches tho.”Source discussion ↗
Ginkgo BilobaMixed
“ginkgo biloba is worthless but it has only done me extremely good with focus and depression and lots of things.”Source discussion ↗
Ginkgo BilobaMixed
“I tried Vinpocetine and gingko biloba for the same effect, but with cero results.”Source discussion ↗
NiacinMostly positive
“If you over methylate, niacin may also help you. Binds to free methyl groups... It's how I fixed my heart palpitations after taking methylsulfonymethan.”Source discussion ↗
NiacinMostly positive
“Been taking Niacin, but other than the flush, I've found it makes me feel kinda irritable after taking it and my stomach doesn't feel great.”Source discussion ↗
NiacinMostly positive
“I take niacin daily and have noticed big improvements in mental clarity / focus.”Source discussion ↗
NiacinMostly positive
“Had bad flushing w/ the niacin. Felt like I was on fire, massive blotching covered entire body.”Source discussion ↗
PhosphatidylserineMostly positive
“A supplement I have never seen on here that works great for me is Phosphatidylserine. Somehow awesome.”Source discussion ↗
PhosphatidylserineMostly positive
“Not feeling any difference.. I find it really weird I don't feel any different than I normally do.. no concentration boost or anything.”Source discussion ↗
PhosphatidylserineMostly positive
“Phosphatidylserine (8/10): ... it made a pretty big impact as far as stress reduction for me. I felt less physical anxiety in social situations...”Source discussion ↗
PhosphatidylserineMostly positive
“within 10-15 minutes if I'm feeling more down to Earth and relaxed...Over the last three weeks, I have seldom had these nervous thought loops.”Source discussion ↗
TadalafilMostly positive
“After a week of 2.5 mg twice a day, this is my favourite drug ever. My brain fog has gone...My mood is so much better, similar to an SSRI but without the flat feeling.”Source discussion ↗
TadalafilMostly positive
“I use it sporadically as a preworkout, 5mg before gym, gets a nice pump going - I always get a stuffy nose and that's about it from side effects that Ive noticed.”Source discussion ↗
TadalafilMostly positive
“It's probably the only drug I've ever taken that's improved my overall mood and impacted my mental health positively. People say it's because the improved blood flow in the brain.”Source discussion ↗
TadalafilMostly positive
“I take it for neuropathy. It’s solved about 95% of the tingling... Also fixed ED. I’m cutting the pills in half so it’s 2.5mg a day but works wonders.”Source discussion ↗
ResveratrolMixed
“started NMN and resveratrol which I can definitely feel a difference and see the sleep has gotten better since.”Source discussion ↗
ResveratrolMixed
“I feel more tired in my body, but mentally sharper. I am quite in tune to my blood sugar levels and it feels like they have dropped.”Source discussion ↗
ResveratrolMixed
“I've heard lots of horror stories about side effects of resveratrol, and it has such a complicated mechanism of action.”Source discussion ↗
ResveratrolMixed
“For me nadh, resveratrol and shilajit (sometimes with coq10) is my unbeatable energy stack.”Source discussion ↗
Horny Goat WeedMixed
“Lately I've been alternating days between black ginger and HGW and I really feel a difference in mood, libido and blood flow.”Source discussion ↗
Horny Goat WeedMixed
“HGW is grand and all but it makes me sore and you're better off taking a proper pde-5.”Source discussion ↗
Horny Goat WeedMixed
“List of things I've tried (some worked, but only for a few days and then never worked again)”Source discussion ↗
Horny Goat WeedMixed
“ND 10% HGW. Better Blood flow and Vascularity. BG however, doesn’t make my chest itchy like HGW (flares my preexisting gyno)”Source discussion ↗