People mainly take Niacin for mood, energy, focus. Based on 136 first-hand reports and 114 meta-analyses & systematic reviews in the medical literature. Ranked #143 of 1,974 overall.
Of reports that state an outcome, 80% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.
PubMed 35365361 ↗Conclusion: In this meta-regression analysis, the use of statin and nonstatin therapies that act via upregulation of LDL receptor expression to reduce LDL-C were associated with similar RRs of major vascular events per change in LDL-C. Lower achieved LDL-C levels were associated with lower rates of major coronary events.
PubMed 27673306 ↗Conclusion: Following a vegan diet may result in deficiencies in micronutrients (vitamin B12, zinc, calcium and selenium) which should not be disregarded. However, low micro- and macronutrient intakes are not always associated with health impairments. Individuals who consume a vegan diet should be aware of the risk of potential dietary deficiencies.
PubMed 33341313 ↗Conclusion: Increased UPF intake correlated with an increase in free sugars, total fats, and saturated fats, as well as a decrease in fiber, protein, potassium, zinc, and magnesium, and vitamins A, C, D, E, B12, and niacin. In conclusion, the data indicate that increased UPF consumption negatively affects the nutritional quality of diets.
PubMed 34684391 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“The niacin is new, love the flush but it's probably not the ideal supplement. I'm taking it for the NAD benefits.”
“my doctor told me niacin helps with cognition”
“100-200 mg and also its the flush kind, it helps the changes from the lions mane and psilocybin pass into the blood stream.”
“Flushing from less than 100 mg of niacin means you have high histamine levels and will likely benefit from SAMe.”
“consider niacin and tea.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate