SAM-E vs Tmg for mood
Short answer: For mood, more users report improvement with SAM-E — 92% of 114 reports, versus 62% of 13 for Tmg.
SAM-E has 3 meta-analyses and 1 randomized trials on PubMed; Tmg has 25 and 47.
Based on 284 reports about SAM-E and 130 about Tmg. Not medical advice.
| SAM-E Supplement | Tmg Supplement | |
|---|---|---|
| Users say it helped | 63%helped131 reports · high confidence | 53%helped25 reports · medium confidence |
| Verdict | Mostly positive | Mixed |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 3 / 1 | 25 / 47 |
| Mainly used for | ||
| Mood % reporting improvement | 92% (114) | 62% (13) |
| Energy % reporting improvement | 87% (23) | 89% (9) |
| Anxiety % reporting improvement | 67% (21) | 33% (3) |
| Focus % reporting improvement | 100% (13) | 100% (2) |
| Sleep % reporting improvement | 33% (3) | 60% (5) |
| Common side effects | insomnia, jitteriness, stomach issues, anxiety | aggression, anger, weird feeling, sleep disturbances |
| Typical dose reported | 200-400 mg / daily | 1000 mg |
Our results showed that robotic surgery contributed positively to some perioperative outcomes but longer operative times remained a shortcoming. Better quality evidence is needed to guide surgical decision making regarding the precise clinical targets of this innovation in the next generation of its use.
Surg Endosc, 2016 ↗“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”
This article is a translated summary of the full version of the ARDS Clinical Practice Guideline 2021 published in Japanese (URL: https://www.jrs.or.jp/publication/jrs_guidelines/). The original text, which was written for Japanese healthcare professionals, may include different perspectives from healthcare professionals of other countries.
Respir Investig, 2022 ↗“I take both creatine and TMG and notice MASSIVE improvements in cognitive function, sleep, and athletic performance from both.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate