SAM-E reviews: what real users say
We read 284 first-hand mentions of SAM-E from health and supplement communities. 131 of them say clearly how it went — and 63% of those say it helped.
Where people say it works: mood (92% of 114), energy (87% of 23), anxiety (67% of 21), focus (100% of 13).
Most common complaints: insomnia, jitteriness, stomach issues, anxiety, drowsiness. All side effects →
Positive experiences
“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”
“Taking SAM-e completely changed my life from total lethargy with the only relief being Adderall or Ritalin to being a functional person, no side effects noticed and I only have to cycle it occasionally.”
“SAMe and agmatine sulfate over the past year to be the two most noticeably helpful supplements i have ever taken for baseline energy/mood.”
“Low and behold it actually worked. Within five days I noticed a difference. The headaches are gone and I wake up everyday feeling refreshed.”
“I had mild success with the supplement SAM-e. It definitely is stimulating—so should be taken in the AM—but no where near what any dedicated focus OTC peptide or supplement blends tend to do to me.”
“sam-e - I'm not yet sure how this makes me feel better, because I take it since few days, but works wonders.”
Negative and mixed experiences
“I just started taking Sam-e and it’s helped with my ADHD and depression tremendously.”
“Took me years to feel normal. Back then I used SAMe to help me.”
“It helped mood and motivation, had more of a desire to get out and do things like be social. Felt like a weaker Wellbutrin to me.”
“I was taking Sam-E for an energy boost when I go for a ride. I no longer take that stuff though because I've heard it disrupts sleep patterns.”
“SAM-e alone had no sleep shortening effect. At the end my natural sleep length increased to ~8.5h. At that point I resumed taking SAM-e.”
“I've seen some amazing improvement in such a short amount of time (even better than SSRI!). After a week, I decided to stop...started experiencing a horrible spike in OCD and anxiety.”
Quotes are verbatim and link to the original public discussion. Information only — not medical advice. How we collect reports