SAM-E side effects
Across 284 first-hand reports, people mentioned a side effect 30 times (about 11 per 100 reports). The most common: insomnia, jitteriness, stomach issues. User reports show what people notice — they can't tell you whether SAM-E is safe for you.
Reported side effects
insomnia8
jitteriness8
stomach issues5
anxiety4
drowsiness2
high prolactin1
hypothyroidism1
anxiety spike1
What got worse for some people
In their own words
“I just started taking Sam-e and it’s helped with my ADHD and depression tremendously.”
“It helped mood and motivation, had more of a desire to get out and do things like be social. Felt like a weaker Wellbutrin to me.”
“I had mild success with the supplement SAM-e. It definitely is stimulating—so should be taken in the AM—but no where near what any dedicated focus OTC peptide or supplement blends tend to do to me.”
“I've seen some amazing improvement in such a short amount of time (even better than SSRI!). After a week, I decided to stop...started experiencing a horrible spike in OCD and anxiety.”
Is SAM-E safe? What the research covers
BResearch: Moderate3 meta-analyses · 1 randomized trials on PubMed
None of the top reviews we found focus on safety. All research on SAM-E.