Saffron vs SAM-E for mood
Short answer: For mood, users rate them about the same: 92% report improvement with Saffron (165 reports) and 92% with SAM-E (114 reports).
Saffron has 88 meta-analyses and 119 randomized trials on PubMed; SAM-E has 3 and 1.
Based on 421 reports about Saffron and 284 about SAM-E. Not medical advice.
| Saffron Supplement | SAM-E Supplement | |
|---|---|---|
| Users say it helped | 62%helped223 reports · high confidence | 63%helped131 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 88 / 119 | 3 / 1 |
| Mainly used for | ||
| Mood % reporting improvement | 92% (165) | 92% (114) |
| Anxiety % reporting improvement | 81% (84) | 67% (21) |
| Focus % reporting improvement | 79% (38) | 100% (13) |
| Energy % reporting improvement | 81% (21) | 87% (23) |
| Sleep % reporting improvement | 72% (18) | 33% (3) |
| Common side effects | headache, appetite suppression, insomnia, vivid dreams | insomnia, jitteriness, stomach issues, anxiety |
| Typical dose reported | 30 mg | 200-400 mg / daily |
Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested.
J Atten Disord, 2024 ↗“I just sneak some into whatever soup we are having. I honestly think it has made a huge difference.”
Our results showed that robotic surgery contributed positively to some perioperative outcomes but longer operative times remained a shortcoming. Better quality evidence is needed to guide surgical decision making regarding the precise clinical targets of this innovation in the next generation of its use.
Surg Endosc, 2016 ↗“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate