SAM-E vs Tianeptine for mood
Short answer: For mood, users rate them about the same: 92% report improvement with SAM-E (114 reports) and 95% with Tianeptine (148 reports).
SAM-E has 3 meta-analyses and 1 randomized trials on PubMed; Tianeptine has 18 and 42.
Based on 284 reports about SAM-E and 322 about Tianeptine. Not medical advice.
| SAM-E Supplement | Tianeptine Medication | |
|---|---|---|
| Users say it helped | 63%helped131 reports · high confidence | 63%helped155 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 3 / 1 | 18 / 42 |
| Mainly used for | ||
| Mood % reporting improvement | 92% (114) | 95% (148) |
| Anxiety % reporting improvement | 67% (21) | 95% (62) |
| Energy % reporting improvement | 87% (23) | 86% (14) |
| Focus % reporting improvement | 100% (13) | 93% (14) |
| Pain & inflammation % reporting improvement | 100% (8) | 67% (3) |
| Common side effects | insomnia, jitteriness, stomach issues, anxiety | addiction, withdrawal, tolerance, headache |
| Typical dose reported | 200-400 mg / daily | Not listed |
Our results showed that robotic surgery contributed positively to some perioperative outcomes but longer operative times remained a shortcoming. Better quality evidence is needed to guide surgical decision making regarding the precise clinical targets of this innovation in the next generation of its use.
Surg Endosc, 2016 ↗“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“It has really improved the quality of my life, more than anything else I have taken.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate