Curcumin vs SAM-E for mood
Short answer: For mood, users rate them about the same: 96% report improvement with Curcumin (45 reports) and 92% with SAM-E (114 reports).
Curcumin has 538 meta-analyses and 553 randomized trials on PubMed; SAM-E has 3 and 1.
Based on 544 reports about Curcumin and 284 about SAM-E. Not medical advice.
| Curcumin Supplement | SAM-E Supplement | |
|---|---|---|
| Users say it helped | 61%helped180 reports · high confidence | 63%helped131 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 538 / 553 | 3 / 1 |
| Mainly used for | ||
| Mood % reporting improvement | 96% (45) | 92% (114) |
| Pain & inflammation % reporting improvement | 91% (104) | 100% (8) |
| Anxiety % reporting improvement | 93% (15) | 67% (21) |
| Energy % reporting improvement | 83% (6) | 87% (23) |
| Focus % reporting improvement | 78% (9) | 100% (13) |
| Common side effects | vivid dreams, headache, nausea, dht suppression | insomnia, jitteriness, stomach issues, anxiety |
| Typical dose reported | 1000 mg / daily | 200-400 mg / daily |
Curcumin and Curcuma longa Extract may improve symptoms and inflammation levels in people with arthritis. However, due to the low quality and small quantity of RCTs, the conclusions need to be interpreted carefully.
Front Immunol, 2022 ↗“I recently stopped taking Curcumin because of its affect on DHT and I was looking for an alternative measure to deal with inflammation as I feel it really helped with anxiety/depression.”
Our results showed that robotic surgery contributed positively to some perioperative outcomes but longer operative times remained a shortcoming. Better quality evidence is needed to guide surgical decision making regarding the precise clinical targets of this innovation in the next generation of its use.
Surg Endosc, 2016 ↗“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate