Clomiphene vs DHEA for hormones
Short answer: For hormones, users rate them about the same: 95% report improvement with Clomiphene (64 reports) and 91% with DHEA (44 reports).
Clomiphene has 218 meta-analyses and 531 randomized trials on PubMed; DHEA has 215 and 637.
Based on 224 reports about Clomiphene and 306 about DHEA. Not medical advice.
| Clomiphene Medication | DHEA Supplement | |
|---|---|---|
| Users say it helped | 53%helped76 reports · medium confidence | 56%helped98 reports · medium confidence |
| Verdict | Mixed | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 218 / 531 | 215 / 637 |
| Mainly used for | ||
| Hormones % reporting improvement | 95% (64) | 91% (44) |
| Mood % reporting improvement | 22% (23) | 87% (30) |
| Libido % reporting improvement | 50% (10) | 91% (32) |
| Energy % reporting improvement | 67% (6) | 92% (26) |
| Performance % reporting improvement | 80% (5) | 75% (4) |
| Common side effects | mood swings, emotional, fatigue, vision sides | acne, vivid dreams, rage, virilization |
| Typical dose reported | Not listed | 25 mg / 1 hour before bed |
Clomiphene citrate increased sperm concentration and motility and could be considered as a safe therapy for improving sperm parameters in infertile males.
Andrology, 2023 ↗“At 35 years old, I literally feel as good as I did in high school again in every aspect: motivation, libido, energy, wellbeing, etc.”
Vaginal estrogen, vaginal DHEA, oral ospemifene, and vaginal moisturizers may improve some GSM symptoms in the short term. Few long-term data exist on efficacy, comparative effectiveness, tolerability, and safety of GSM treatments.
Ann Intern Med, 2024 ↗“DHEA, minimum 50 mg was a huge game changer for my wife. More energy, libido, dopamine/happy mood, concentration- everything.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate