DHEA vs Enclomiphene for hormones
Short answer: For hormones, users rate them about the same: 91% report improvement with DHEA (44 reports) and 90% with Enclomiphene (137 reports).
DHEA has 215 meta-analyses and 637 randomized trials on PubMed; Enclomiphene has 2 and 3.
Based on 306 reports about DHEA and 545 about Enclomiphene. Not medical advice.
| DHEA Supplement | Enclomiphene Medication | |
|---|---|---|
| Users say it helped | 56%helped98 reports · medium confidence | 59%helped185 reports · high confidence |
| Verdict | Mixed | Mixed |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 215 / 637 | 2 / 3 |
| Mainly used for | ||
| Hormones % reporting improvement | 91% (44) | 90% (137) |
| Libido % reporting improvement | 91% (32) | 70% (30) |
| Mood % reporting improvement | 87% (30) | 64% (22) |
| Energy % reporting improvement | 92% (26) | 77% (13) |
| Sleep % reporting improvement | 100% (5) | 75% (4) |
| Common side effects | acne, vivid dreams, rage, virilization | eye floaters, vision issues, mood swings, hair loss |
| Typical dose reported | 25 mg / 1 hour before bed | Not listed |
Vaginal estrogen, vaginal DHEA, oral ospemifene, and vaginal moisturizers may improve some GSM symptoms in the short term. Few long-term data exist on efficacy, comparative effectiveness, tolerability, and safety of GSM treatments.
Ann Intern Med, 2024 ↗“DHEA, minimum 50 mg was a huge game changer for my wife. More energy, libido, dopamine/happy mood, concentration- everything.”
SERM therapy is associated with significantly improved levels of TT, LH, and FSH in hypogonadal men compared to placebo, and significantly enhanced levels of LH and FSH compared to T gel. The findings suggest that SERM therapy effectively increases TT levels in men with functional hypogonadism and should be considered as an alternative to T gel therapy.
Arch Endocrinol Metab, 2025 ↗“I second Enclomiphene citrate. Been on 12.5mg per day sublingual pill and my test went from 430 to 950. No side effects other than being more horny.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate