Clomiphene vs Enclomiphene for hormones
Short answer: For hormones, more users report improvement with Clomiphene — 95% of 64 reports, versus 90% of 137 for Enclomiphene.
Clomiphene has 218 meta-analyses and 531 randomized trials on PubMed; Enclomiphene has 2 and 3.
Based on 224 reports about Clomiphene and 545 about Enclomiphene. Not medical advice.
| Clomiphene Medication | Enclomiphene Medication | |
|---|---|---|
| Users say it helped | 53%helped76 reports · medium confidence | 59%helped185 reports · high confidence |
| Verdict | Mixed | Mixed |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 218 / 531 | 2 / 3 |
| Mainly used for | ||
| Hormones % reporting improvement | 95% (64) | 90% (137) |
| Mood % reporting improvement | 22% (23) | 64% (22) |
| Libido % reporting improvement | 50% (10) | 70% (30) |
| Energy % reporting improvement | 67% (6) | 77% (13) |
| Performance % reporting improvement | 80% (5) | 40% (5) |
| Common side effects | mood swings, emotional, fatigue, vision sides | eye floaters, vision issues, mood swings, hair loss |
| Typical dose reported | Not listed | Not listed |
Clomiphene citrate increased sperm concentration and motility and could be considered as a safe therapy for improving sperm parameters in infertile males.
Andrology, 2023 ↗“At 35 years old, I literally feel as good as I did in high school again in every aspect: motivation, libido, energy, wellbeing, etc.”
SERM therapy is associated with significantly improved levels of TT, LH, and FSH in hypogonadal men compared to placebo, and significantly enhanced levels of LH and FSH compared to T gel. The findings suggest that SERM therapy effectively increases TT levels in men with functional hypogonadism and should be considered as an alternative to T gel therapy.
Arch Endocrinol Metab, 2025 ↗“I second Enclomiphene citrate. Been on 12.5mg per day sublingual pill and my test went from 430 to 950. No side effects other than being more horny.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate