What people actually say
614 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
ALAMostly positive
“I also take alcar, alpha lipoic acid, choline, and pqq, but... there is some difference with these, but not as major as with CoQ10.”Source discussion ↗
ALAMostly positive
“ALCAR+alpha lipoic acid works as well as Adderall. Actually, it's a bit better for me—it wears off more slowly and doesn't interfere with sleep the way Adderall does.”Source discussion ↗
ALAMostly positive
“ALA fixed the issue almost instantly, so I usually don't take ALCAR without the ALA.”Source discussion ↗
ALAMostly positive
“R-ALA - has shrunk keloids that I was told would never go away and helped with general over all MS body pain”Source discussion ↗
Whey ProteinMostly positive
“Coffee with cream, has to be a cream or fake creamer with a whey protein, doesn't. It gives me a gentle but potent energy boost with no headache and no jitters.”Source discussion ↗
Whey ProteinMostly positive
“I stopped taking whey protein. Almost all brands have sucralose, which has questionable effects on gut biome.”Source discussion ↗
Whey ProteinMostly positive
“I do notice they help significantly but i cannot tolerate them (yes, I have tried concentrate, isolate and hydro), I start to bloat a lot and feel a bit nauseous.”Source discussion ↗
Whey ProteinMostly positive
“In my case I feel mentally more relaxed ever since I started taking 4 scoops of whey protein per day. I also notice more endurance in the gym.”Source discussion ↗
SAM-EMostly positive
“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”Source discussion ↗
SAM-EMostly positive
“I just started taking Sam-e and it’s helped with my ADHD and depression tremendously.”Source discussion ↗
SAM-EMostly positive
“Taking SAM-e completely changed my life from total lethargy with the only relief being Adderall or Ritalin to being a functional person, no side effects noticed and I only have to cycle it occasionally.”Source discussion ↗
SAM-EMostly positive
“SAMe and agmatine sulfate over the past year to be the two most noticeably helpful supplements i have ever taken for baseline energy/mood.”Source discussion ↗
Intermittent FastingMostly positive
“I would suggest trying Intermittent fasting. I have much better focus and clarity.”Source discussion ↗
Intermittent FastingMostly positive
“When I did intermittent fasting I got along OK and feel good if I drink enough water.”Source discussion ↗
Intermittent FastingMostly positive
“I also did intermittent fasting for the first 4 months and lost my first 50 lbs that way.”Source discussion ↗
Intermittent FastingMostly positive
“Have you tried intermittent fasting? That cleared up my brain fog when a lot of other things didn't help.”Source discussion ↗
ResveratrolMixed
“started NMN and resveratrol which I can definitely feel a difference and see the sleep has gotten better since.”Source discussion ↗
ResveratrolMixed
“I feel more tired in my body, but mentally sharper. I am quite in tune to my blood sugar levels and it feels like they have dropped.”Source discussion ↗
ResveratrolMixed
“I've heard lots of horror stories about side effects of resveratrol, and it has such a complicated mechanism of action.”Source discussion ↗
ResveratrolMixed
“For me nadh, resveratrol and shilajit (sometimes with coq10) is my unbeatable energy stack.”Source discussion ↗
EphedrineMixed
“Ephedrine gives me tons of energy, makes me happy, positive, and talkative. It's an excellent pre-workout, though it doesn't suppress my appetite like it's supposed.”Source discussion ↗
EphedrineMixed
“This morning I had about 200mg of caffeine with ephedrine pre-workout because I didnt get the best sleep last night. I could not focus at ALL today at work.”Source discussion ↗
EphedrineMixed
“with 100mg caffeine, 200mg theanine, and 25mg ephedrine I still get pretty jittery. I've been taking 25 mg Ephedrine, 200 caffeine, 450 suntheanine, and 325 aspirin (not as a nootropic, to promote fat loss). Works pretty well for me.”Source discussion ↗
EphedrineMixed
“closest thing to adderall is ephedrine. I current switched from the ECA stack to the ECY stack (ephedrine, caffeine, Yohimbine) and it's working better for me.”Source discussion ↗
TesamorelinMixed
“I also added Tesamorelin 2 months in due to the harder time sleeping on Retatrutide and wanting to accelerate the burn of my visceral fats (2mg 5x a week). Worked like magic for me.”Source discussion ↗
TesamorelinMixed
“I now have my tesa early morning still fasted from Monday to Friday. My Reta Friday mornings as well. No tesa or Reta on weekends, and found my sleep improved dramatically.”Source discussion ↗
TesamorelinMixed
“Did a quick Reta run, then slowed that down and started the GH journey. And it has been great. I feel a lot stronger and my endurance has boosted!”Source discussion ↗
TesamorelinMixed
“I did an eight week cycle of tesamorelin 2mg/day on week days, weekends off, and it went really well. I definitely lost fat, gained muscle, and I look and feel a ton healthier.”Source discussion ↗
TadalafilMostly positive
“After a week of 2.5 mg twice a day, this is my favourite drug ever. My brain fog has gone...My mood is so much better, similar to an SSRI but without the flat feeling.”Source discussion ↗
TadalafilMostly positive
“I use it sporadically as a preworkout, 5mg before gym, gets a nice pump going - I always get a stuffy nose and that's about it from side effects that Ive noticed.”Source discussion ↗
TadalafilMostly positive
“It's probably the only drug I've ever taken that's improved my overall mood and impacted my mental health positively. People say it's because the improved blood flow in the brain.”Source discussion ↗
TadalafilMostly positive
“I take it for neuropathy. It’s solved about 95% of the tingling... Also fixed ED. I’m cutting the pills in half so it’s 2.5mg a day but works wonders.”Source discussion ↗
Milk ThistleMostly positive
“Adrafinil and milk thistle is my current best solution...Milk thistle helps for the hepatoxicity (as you know)”Source discussion ↗
Milk ThistleMostly positive
“Nothing much happened. I still had those problems after trying all that nootropics and supplements.”Source discussion ↗
Milk ThistleMostly positive
“Milk thistle can with some people cause Hypothyroidism... I had to quit taking I started gaining weight and my thyroid was swollen and hurt.”Source discussion ↗
Milk ThistleMostly positive
“I have improved taking milk thistle which helps my liver heal and to detoxify toxins.”Source discussion ↗
PregnenoloneMixed
“I know pregnenalone helped me with that anxiety... 25mg a day is wonderful.”Source discussion ↗
PregnenoloneMixed
“Now it's like 90% fixed by pregnenolone. However, I been taking around 10 to 20 mg this is the sweet spot for me if I take anymore I get the opposite reaction such as more fatigue and tiredness.”Source discussion ↗
PregnenoloneMixed
“I've been taking pregnenolone, dhea, and tongkhat ali and it helps keep my mind straight while living alone, working alone.”Source discussion ↗
PregnenoloneMixed
“I've never felt more comfortable in my own skin, more calm, or stable. Things just feel right. But: Definitely not a keeper for me. Either no effect or I get more jittery/anxious.”Source discussion ↗