Conclusion: Women with anorexia nervosa have higher cortisol levels and lower DHEA-S and testosterone levels compared to women without anorexia nervosa. This finding is important to consider when evaluating low-weight women for disorders involving the adrenal axis, especially Cushing's syndrome.
PubMed 37669399 ↗Pregnenolone
People mainly take Pregnenolone for mood, anxiety, libido. Based on 65 first-hand reports and 12 meta-analyses & systematic reviews in the medical literature. Ranked #318 of 1,974 overall.
Of reports that state an outcome, 60% are positive.
What Pregnenolone does, according to users
Of the people who reported each effect, the share who said it got better.
4 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: In this paper, we have reviewed various researches conducted on N. incisum especially in areas of its ethnopharmacological use, phytochemicals, pharmacology and developed analytical methods. This herb has been used over the years in treating headache, rheumatoid arthritis, cold, diaphoretic etc, prompting many types of research into identifying which compounds are responsible for these activities and their mechanism of action. More research is needed in the area of pharmacokinetics and toxicology to give further information on the clinical use and control the quality of the herb.
PubMed 28336469 ↗Conclusion: Estrogens and SERMs could be effective augmentation strategies in the treatment of women with schizophrenia, although potential side effects, partially associated with longer duration use, should be taken into account. Future trials are needed to study long-term effects and effects on cognition.
PubMed 25914107 ↗Conclusion: Some, but not all agents with anti-inflammatory properties showed efficacy. Effective agents were aspirin, estrogens, minocycline, and NAC. We observed greater beneficial results on symptom severity in FEP or early-phase schizophrenia.
PubMed 31439071 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“Pregnenolone increases time spent in deep sleep. ... Take it in the morning.”
“I use it with benefit, but only after I tested low in it. Wouldn’t encourage anyone to take it without getting their levels checked first.”
“I just bought some pregnenalone as well haven't tried it yet.”
“Pregnenolone - increases neurogenesis”
“For anxiety you should try pregnenolone, a naturally occurring hormone”
Top discussions (5)
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- I was permanently and severely damaged by a medication I took in 2019. ↗
- Vitamin K deficiency reduces testosterone production in rats (2006) ↗
Other options for mood
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate