PlainPill

Pregnenolone

People mainly take Pregnenolone for mood, anxiety, libido. Based on 65 first-hand reports and 12 meta-analyses & systematic reviews in the medical literature. Ranked #318 of 1,974 overall.

34
User score
Mixed
25% positive14% mixed3% negative58% unclear

Of reports that state an outcome, 60% are positive.

Clinical research
AStrong research base
12
meta-analyses
36
RCTs
5,993
papers

What Pregnenolone does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

J Ethnopharmacol · 2017 · Meta-analysis / systematic review
A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisum

Conclusion: In this paper, we have reviewed various researches conducted on N. incisum especially in areas of its ethnopharmacological use, phytochemicals, pharmacology and developed analytical methods. This herb has been used over the years in treating headache, rheumatoid arthritis, cold, diaphoretic etc, prompting many types of research into identifying which compounds are responsible for these activities and their mechanism of action. More research is needed in the area of pharmacokinetics and toxicology to give further information on the clinical use and control the quality of the herb.

PubMed 28336469 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

morningas reported
5 mg2x daily
100 mg (or 50 mg)daily
10 mgdaily
25 mgdaily
5 mgas reported

Reported side effects

How often each side effect came up across all reports.

anxiety ×3jitteriness ×2withdrawal ×1rage ×1irritability ×1hair loss ×1nervousness ×1dysphoria ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Pregnenolone increases time spent in deep sleep. ... Take it in the morning.”
Source discussion ↗
“I use it with benefit, but only after I tested low in it. Wouldn’t encourage anyone to take it without getting their levels checked first.”
Source discussion ↗
“I just bought some pregnenalone as well haven't tried it yet.”
Source discussion ↗
“Pregnenolone - increases neurogenesis”
Source discussion ↗
“For anxiety you should try pregnenolone, a naturally occurring hormone”
Source discussion ↗
Top discussions (5)

Other options for mood

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate