PlainPill

What people actually say

694 first-hand quotes, shortened but never edited — each links to the original discussion.

AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
Aerobic ExerciseMostly positive
“I want to do regular HIIT 3 times a week, but there are days where I feel absolutely terrible”
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Aerobic ExerciseMostly positive
“exercise though it may be difficult to start always helped me when I was down”
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VortioxetineMostly negative
“I feel a lot better with antidepressants, I can remember things again... I can sleep again... I have again libido and I haven't suicide ideation anymore”
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VortioxetineMostly negative
“Vortioxetine ended up improving my mood, lowering my anxiety and had much less emotional and sexual side effects... it also started to decrease my motivation and cause lethargy.”
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VortioxetineMostly negative
“I recently came off vortioxetine 20mg because it made my anxiety a lot worse.”
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VortioxetineMostly negative
“testing out depression and anxiety medicines, 10mg brintellix (trintellix/vortioxetine) and 250-500mcg xanor (xanax/alprazolam). They seem to not help me after 1,5 months.”
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“standard dose for modafinil is 200 - 400mg at once, and I can go through 40mg of Dexamphetamine (I'm prescribed it for ADHD)”
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“These work great for my focus and motivation, but I get awful come downs after the 4 hours and invariably end up sobbing my eyes out for an hour or two.”
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“40mg dose: lost about 80 percent of my hearing... heart rate ramped up... could not think to save my life”
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“It was the perfect medicine for my condition but eventually increased dosage due to tolerance and got addicted”
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“By far the most impressive substance I have tried so far...clears brain fog, increases mental energy, lowers anxiety (especially in social situations), lowers perceived stress levels and improves my memory.”
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“INI reduced my anxiety (its only benefit). INI made me kind of dumber like I could not think clearly.”
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“Every day I do 120 practice questions and now I knock them out in a few hours like they’re nothing.”
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“what ended up working best for me was Intranasal insulin. It is definitely good enough to be used as a stand alone nootropic, not only significantly clear up brain fog but to also boost mood+energy+cognition... all for $26 a month”
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“500% of my daily intake of B-complexes...helped my memory and function like crazy”
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“way back I tried some B-complex vitamins and L-theanine which helped but not that much.”
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“Some stuff I have tried is B12 and B complex vitamins... Haven't really noticed much of anything”
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“B vitamins helped my energy a lot :)”
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IDRA-21Mixed
“IDRA-21. It's incredible for focus, memory, it can reverse dementia and Alzheimer effects in elderly. I have never felt so focused and clear headed than I do on IDRA”
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IDRA-21Mixed
“I did 3 or 4 days consecutive on it and it stopped due to some negative manic side effects”
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IDRA-21Mixed
“i've tried a bunch of different nootropics, i think the best ones for me have been noopept, fasoracetam, idra-21. onlything that really helped me remeber 2-3 chapter in a mathbook was idra-21”
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IDRA-21Mixed
“I weigh out exactly 5 milligrams of IDRA-21...everything was more *static*, I perceived the surroundings as if they were under my control”
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TulsiMostly positive
“There's a compound in Tulsi or known as Holy Basil that minimizes the memory effect. Make a tea out of it, that's fairly strong and have a few cups - memory solved. Has worked magic for me.”
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TulsiMostly positive
“A better alternative for me was Tulsi (Holy Basil). It took me a couple of days to get out of that body fog.”
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TulsiMostly positive
“I also take Tulsi which helps as well”
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TulsiMostly positive
“I like l-theanine, lemon balm and tulsi for anxiety”
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“Then I tried mushrooms a few times and that helped me feel a connection to the earth and soil, but more importantly helped me better assign positive emotions to memories”
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“I did mushrooms for the first time about a week ago. 2 grams only. I felt weird and giggly for several hours, but certainly nothing like a breakthrough... I felt pretty good the next day but tired. Didn't feel like it changed me, though.”
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“I have found that shrooms are more than likely what exacerbated my symptoms.”
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“I find certain mushrooms to be very uplifting...My mushies just started pinning! 😂 I find them very helpful as well.”
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Smart PsMostly positive
“Smart PS : amazing memory and focus improvement. I take it in the morning , indirectly helps sleep and i feel less anxious/nervous overall.”
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Smart PsMostly positive
“I usually sing ND's praises at any oportunity given, but I never felt smart PS worked all that well.”
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Smart PsMostly positive
“I took it in the afternoon and felt helpless and demotivated until I went to bed. Dropping cortisol can absolutely affect your energy and motivation negatively”
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Smart PsMostly positive
“I've also heard of some people having great sleep effects with SmartPS”
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DonepezilMostly positive
“This is by far the number 1 nootropic in the world in my eyes. Nothing even comes close to this one.”
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DonepezilMostly positive
“I think it helps with my overall cognition. It definitely helps with reading comprehension...I take a low dose, however, like 1.25 mg”
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DonepezilMostly positive
“I'm planning on implementing donezeil for its memory benefits... slowly tapering up to 10mg a day.”
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Blueberry ExtractMostly positive
“I like: Blueberry, Caffeine, Creatine, Curcumin, Fish Oil, Garlic, Ginger, Maca, Melatonin, Minoxidil, Modafinil, Spirulina”
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Blueberry ExtractMostly positive
“I took some tests this week to see if I notice any difference in my IQ. Visual/geometrical problems are fine... I have blueberry in tablet form and I use it now.”
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Blueberry ExtractMostly positive
“I just started taking ALCAR , L tyrosine , Rhodiola Rosea , holy basil , omega 3 , ashwaganda , L theanine and caffiene , Curcumin and blueberry affect . I’m legit starting to feel my brain fog lift”
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User reports — what people say about supplements — PlainPill