People mainly take Donepezil for memory, focus, sleep. Based on 8 first-hand reports and 221 meta-analyses & systematic reviews in the medical literature. Ranked #868 of 1,974 overall.
Of reports that state an outcome, 100% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: ChEIs, memantine, and GV-971 all can slow the progression of AD but have different effects on respective assessments. Donepezil and GV-971 were relatively well tolerated.
PubMed 38640313 ↗Conclusion: High-level evidence related to pharmacological strategies for managing Lewy body dementia is rare. Strategies for important areas of need in Lewy body dementia, such as autonomic symptoms and caregiver burden, have not been investigated, nor have the views of patients and caregivers about pharmacological strategies.
PubMed 26085043 ↗Conclusion: Here we show the significant effects of all available acetylcholinesterase inhibitors on cognitive function in patients with AD. However, further studies are needed to draw valid conclusions about the effects of acetylcholinesterase inhibitors on functional outcomes and adverse events.
PubMed 38439609 ↗Conclusion: α-GPC alone or in combination with donepezil improved cognition, behavior, and functional outcomes among patients with neurological conditions associated with cerebrovascular injury.
PubMed 36683513 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Donazepil”
“we will be using either the Alzheimer's drug, Donepezil, or the herbal Huperzine A”
“This is by far the number 1 nootropic in the world in my eyes. Nothing even comes close to this one.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate