PlainPill

What people actually say

1,588 first-hand quotes, shortened but never edited — each links to the original discussion.

AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
“I really got better from anxiety ... on effexor. My personal miracle drug does not work for everyone.”
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“I tried Venlafaxine and my ADHD improved significantly. However, it also had a certain amount of excitotoxicity, and I couldn't sleep at night.”
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“I started Venlafaxine three months ago when I got depressed again...and it got me out of bed, but NAC was the game changer for me.”
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“I found that Venlafaxine was good once it down regulated my norephineprine. Before I was constantly full of somatic anxiety but now it’s definitely improved.”
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SSRIMostly negative
“then i came to SSRI , it helped a little bit then.”
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SSRIMostly negative
“I only took them for those 25 days and quit because it made me feel 100% numb with zero emotions or pleasure.”
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SSRIMostly negative
“Started doing some therapy and an SSRI, and saw huge improvement in all my symptoms.”
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SSRIMostly negative
“I decided to try an SSRI one day and now my life has completely changed. Anxiety is gone, obsessive behavior/rituals are gone, agoraphobia is gone.”
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IbuprofenMostly positive
“I've always had a positive response to ibuprofen and would take it morning and night if it wasn't for the side effects and agmatine provides the same anti-depressant effects of ibuprofen.”
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IbuprofenMostly positive
“I take 1600mgs of advil and a 100mgs of zinc supplements a night. Have noticed absolutely nothing. Except better sleep.”
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IbuprofenMostly positive
“I find curcumin works just as well, if not better, than ibuprofen.”
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IbuprofenMostly positive
“I tried paracetamol, ibuprofen, tramadol(all painkillers) and methyl salicylate to decrease inflammation prescribed by my doctor but nothing is working.”
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MDMAMixed
“I feel that MDMA changed my personality forever, in a good way.”
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MDMAMixed
“Probably great for PTSD but it did nothing really for me. I mean great experience but against depressive or anxiety symptoms it doesn't do shit long-term.”
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MDMAMixed
“I took my 200mg dose and felt absolutely nothing. The only thing I got out of it was the inability to sleep, and urinate.”
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MDMAMixed
“Fantastic. Helped my think through alot of the things I was ruminating over.”
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ThiamineMostly positive
“I'll take a little extra (esp of b1) and physically feel calmer within the hour.”
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ThiamineMostly positive
“As for Vitamin B1 (Thiamine) I found there is a initial result if your body is deficient after that it's not noticeable.”
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ThiamineMostly positive
“Thiamine is vitamin B1, it is very stimulating, and I actually crash a little from it.”
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ThiamineMostly positive
“I already had good experiences with Gotu Kola, Lemon Balm, Inositol, Thiamine and Black Seed Oil for mood & anxiety”
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WaterMostly positive
“200mg did NOT give any pains when I consumed 20 fl ounces of water with it. Modafinil definitely requires high water intake.”
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WaterMostly positive
“I find drinking 2-litres during the day before drinking makes a big difference.”
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WaterMostly positive
“Drink ample amount of water. I am able to get better erections on days when I drink ample water as compared to days when I don't drink enough water.”
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WaterMostly positive
“chug a 32 ounce drink of water. The more I drink water the less I feel like eating at all”
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Polygala TenuifoliaMostly positive
“150mg had immediate antidepressant effects for me. It's worked great for mood and focus...It has improved my depression, anhedonia, and ADHD all at once.”
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Polygala TenuifoliaMostly positive
“Polygala is mildly stimulating, but for me it was all dirty-feeling, anxiogenic stimulation.”
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Polygala TenuifoliaMostly positive
“I didn't realize quite how well it was working until I ran out and my brain once again turned to mush.”
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Polygala TenuifoliaMostly positive
“I've actually taken every one of these and I feel each one acutely.”
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NaltrexoneMostly positive
“I tried to quit drinking hundreds of times... I tried a new method and it was super easy and a major life upgrade. It's simple, you take Naltrexone every morning... you don't get that horrific 'chasing the dragon' effect.”
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NaltrexoneMostly positive
“LDN didn't work for me and made me miserable after the first few doses.”
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NaltrexoneMostly positive
“I took low dose Naltrexone 4.5mg and after 30 years of drinking daily did not have cravings when I quit 8 months ago. Game changer!”
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NaltrexoneMostly positive
“The low dose naltrexone was the game changer for my fibromyalgia pain.”
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EggsMostly positive
“I now eat eggs and steak for breakfast and feel so much better. No bloating. No blood sugar crash.”
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EggsMostly positive
“I absolutely love eggs, I just feel better when I use them.”
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EggsMostly positive
“I feel a little smarter after eating these foods: dark chocolate, liver, cold pressed green juice, eggs, and salmon eggs/ roe.”
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EggsMostly positive
“Adding egg yolks and red meat back into my diet really helped me get rid of my brain fog and anxiety.”
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Dl-PhenylalanineMostly positive
“DL-Phenylalanine has been life changing for me... It's not expensive and it is extremely helpful for my mind, energy, and focus.”
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Dl-PhenylalanineMostly positive
“I feel more energy and focus. Even my mood is better. It works every time and the effect is really niticible. But after 30 minutes or more, I start to feel anxiety”
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Dl-PhenylalanineMostly positive
“DL-Phenylalanine (DLPA) paired with a B-Complex provides me with a nice energy/focus boost.”
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Dl-PhenylalanineMostly positive
“I started taking high dose selegiline and moclobemide with d,l-phenylalanine... my anxiety as well as anhedonia have been abolished.”
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