People mainly take Naltrexone for appetite, weight loss, mood. Based on 10 first-hand reports and 317 meta-analyses & systematic reviews in the medical literature. Ranked #484 of 1,974 overall.
Of reports that state an outcome, 100% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: In conjunction with psychosocial interventions, these findings support the use of oral naltrexone at 50 mg/d and acamprosate as first-line pharmacotherapies for alcohol use disorder.
PubMed 37934220 ↗Conclusion: Tirzepatide was effective in remission of obstructive sleep apnea syndrome and metabolic dysfunction-associated steatohepatitis. These results support the need to individualize the selection of OMMs.
PubMed 41039116 ↗Conclusion: In adults with overweight and obesity, phentermine-topiramate and GLP-1 receptor agonists proved the best drugs in reducing weight; of the GLP-1 agonists, semaglutide might be the most effective.
PubMed 38582569 ↗Conclusion: Obesity drugs produce variable weight loss at one year, with larger benefits generally accompanied by greater harms and discontinuation. Most agents do not improve quality of life meaningfully and few show cardiovascular benefits. Decisions in clinical practice should consider trade-offs between benefits and harms within the context of shared decision making.
PubMed 42419792 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“currently on Naltrexone for treatment”
“I tried to quit drinking hundreds of times... I tried a new method and it was super easy and a major life upgrade. It's simple, you take Naltrexone every morning... you don't get that horrific 'chasing the dragon' effect”
“I took low dose Naltrexone 4.5mg and after 30 years of drinking daily did not have cravings when I quit 8 months ago. Game changer!”
“Wellbutrin and naltrexone has shown great efficacy for aiding in quitting methamphetamine.”
“Naltorexone for the hypothyroidism which is supposedly hashimoto”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate