Kanna vs SAM-E for mood
Short answer: For mood, users rate them about the same: 94% report improvement with Kanna (84 reports) and 92% with SAM-E (114 reports).
Kanna has 8 meta-analyses and 0 randomized trials on PubMed; SAM-E has 3 and 1.
Based on 231 reports about Kanna and 284 about SAM-E. Not medical advice.
| Kanna Supplement | SAM-E Supplement | |
|---|---|---|
| Users say it helped | 77%helped102 reports · high confidence | 63%helped131 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | BResearch: Moderate |
| Meta-analyses / RCTs | 8 / 0 | 3 / 1 |
| Mainly used for | ||
| Mood % reporting improvement | 94% (84) | 92% (114) |
| Anxiety % reporting improvement | 88% (42) | 67% (21) |
| Energy % reporting improvement | 92% (13) | 87% (23) |
| Focus % reporting improvement | 100% (6) | 100% (13) |
| Pain & inflammation % reporting improvement | — | 100% (8) |
| Common side effects | drowsiness, appetite suppression, brain fog, agitation | insomnia, jitteriness, stomach issues, anxiety |
| Typical dose reported | 300mg sublingual | 200-400 mg / daily |
Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.
Nat Genet, 2024 ↗“Kanna tablets. Dissolve under the tongue...I can't sing Kannas praises enough. It's the instant cure for my brain fog, lack of energy, and lack of motivation.”
Our results showed that robotic surgery contributed positively to some perioperative outcomes but longer operative times remained a shortcoming. Better quality evidence is needed to guide surgical decision making regarding the precise clinical targets of this innovation in the next generation of its use.
Surg Endosc, 2016 ↗“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”
Related comparisons
Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate