Kanna vs Tianeptine for mood
Short answer: For mood, users rate them about the same: 94% report improvement with Kanna (84 reports) and 95% with Tianeptine (148 reports).
Kanna has 8 meta-analyses and 0 randomized trials on PubMed; Tianeptine has 18 and 42.
Based on 231 reports about Kanna and 322 about Tianeptine. Not medical advice.
| Kanna Supplement | Tianeptine Medication | |
|---|---|---|
| Users say it helped | 77%helped102 reports · high confidence | 63%helped155 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 8 / 0 | 18 / 42 |
| Mainly used for | ||
| Mood % reporting improvement | 94% (84) | 95% (148) |
| Anxiety % reporting improvement | 88% (42) | 95% (62) |
| Energy % reporting improvement | 92% (13) | 86% (14) |
| Focus % reporting improvement | 100% (6) | 93% (14) |
| Libido % reporting improvement | 100% (8) | — |
| Common side effects | drowsiness, appetite suppression, brain fog, agitation | addiction, withdrawal, tolerance, headache |
| Typical dose reported | 300mg sublingual | Not listed |
Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.
Nat Genet, 2024 ↗“Kanna tablets. Dissolve under the tongue...I can't sing Kannas praises enough. It's the instant cure for my brain fog, lack of energy, and lack of motivation.”
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“It has really improved the quality of my life, more than anything else I have taken.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate