Enclomiphene vs Nolvadex for hormones
Short answer: For hormones, more users report improvement with Nolvadex — 97% of 36 reports, versus 88% of 96 for Enclomiphene.
Enclomiphene has 2 meta-analyses and 3 randomized trials on PubMed; Nolvadex has 6 and 22.
Based on 373 reports about Enclomiphene and 189 about Nolvadex. Not medical advice.
| Enclomiphene Medication | Nolvadex Medication | |
|---|---|---|
| User score | 45 | 47 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 61% | 70% |
| Reports | 373 | 189 |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 2 / 3 | 6 / 22 |
| Mainly used for | ||
| Focus % reporting improvement | 50% (2) | — |
| Energy % reporting improvement | 70% (10) | 100% (3) |
| Sleep % reporting improvement | 75% (4) | — |
| Anxiety % reporting improvement | 0% (2) | — |
| Mood % reporting improvement | 65% (17) | — |
| Performance % reporting improvement | 33% (3) | 50% (2) |
| Recovery % reporting improvement | 100% (2) | — |
| Libido % reporting improvement | 71% (24) | 100% (2) |
| Hormones % reporting improvement | 88% (96) | 97% (36) |
| Common side effects | eye floaters, blurry vision, mood swings, fatigue | fatigue, depression, mood swings, brain fog |
| Typical dose reported | 12.5 g daily (comment; likely mg) / daily for 2 months (comment) | 20 mg / daily |
SERM therapy is associated with significantly improved levels of TT, LH, and FSH in hypogonadal men compared to placebo, and significantly enhanced levels of LH and FSH compared to T gel. The findings suggest that SERM therapy effectively increases TT levels in men with functional hypogonadism and should be considered as an alternative to T gel therapy.
Arch Endocrinol Metab, 2025 ↗“I second Enclomiphene citrate. Been on 12.5mg per day sublingual pill and my test went from 430 to 950. No side effects other than being more horny.”
The current debate is centered on whether the optimal strategy is to give an aromatase inhibitor initially or after several years of tamoxifen treatment. Multiple important questions remain, including the predictive value of molecular markers such as progesterone receptor, the optimal duration of aromatase inhibitor therapy, the long-term adverse effects, and the relative efficacy and toxicity of the different aromatase inhibitors.
Clin Cancer Res, 2006 ↗“This is now 2nd day on nolva and I swaer my balls are about back to normal. Energy is a bit better”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate