Enclomiphene vs Testosterone for hormones
Short answer: For hormones, users rate them about the same: 88% report improvement with Enclomiphene (96 reports) and 90% with Testosterone (91 reports).
Enclomiphene has 2 meta-analyses and 3 randomized trials on PubMed; Testosterone has 75 and 125.
Based on 373 reports about Enclomiphene and 822 about Testosterone. Not medical advice.
| Enclomiphene Medication | Testosterone Medication | |
|---|---|---|
| User score | 45 | 54 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 61% | 77% |
| Reports | 373 | 822 |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 2 / 3 | 75 / 125 |
| Mainly used for | ||
| Weight loss % reporting improvement | — | 93% (45) |
| Focus % reporting improvement | 50% (2) | 82% (28) |
| Energy % reporting improvement | 70% (10) | 92% (76) |
| Sleep % reporting improvement | 75% (4) | 79% (19) |
| Anxiety % reporting improvement | 0% (2) | 80% (25) |
| Mood % reporting improvement | 65% (17) | 88% (104) |
| Memory % reporting improvement | — | 100% (2) |
| Performance % reporting improvement | 33% (3) | 97% (149) |
| Recovery % reporting improvement | 100% (2) | 91% (23) |
| Pain & inflammation % reporting improvement | — | 67% (6) |
| Libido % reporting improvement | 71% (24) | 93% (70) |
| Hormones % reporting improvement | 88% (96) | 90% (91) |
| Heart & lipids % reporting improvement | — | 62% (8) |
| Skin & hair % reporting improvement | — | 40% (5) |
| Longevity % reporting improvement | — | 50% (2) |
| Common side effects | eye floaters, blurry vision, mood swings, fatigue | suppression, hair loss, acne, water retention |
| Typical dose reported | 12.5 g daily (comment; likely mg) / daily for 2 months (comment) | 200 mg / weekly |
SERM therapy is associated with significantly improved levels of TT, LH, and FSH in hypogonadal men compared to placebo, and significantly enhanced levels of LH and FSH compared to T gel. The findings suggest that SERM therapy effectively increases TT levels in men with functional hypogonadism and should be considered as an alternative to T gel therapy.
Arch Endocrinol Metab, 2025 ↗“I second Enclomiphene citrate. Been on 12.5mg per day sublingual pill and my test went from 430 to 950. No side effects other than being more horny.”
The guidelines also provide recommendations regarding identification of patients, dosing, monitoring, and follow-up. This Practice Pearl will discuss evidence-based testosterone therapy for management of HSDD in postmenopausal women.
Menopause, 2023 ↗“Feel the best I've ever felt in my life. TRT and peptides have been game changers for me!”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate