DHEA vs Tamoxifen for hormones
Short answer: For hormones, more users report improvement with Tamoxifen — 98% of 49 reports, versus 91% of 44 for DHEA.
DHEA has 215 meta-analyses and 637 randomized trials on PubMed; Tamoxifen has 479 and 1,597.
Based on 306 reports about DHEA and 298 about Tamoxifen. Not medical advice.
| DHEA Supplement | Tamoxifen Medication | |
|---|---|---|
| Users say it helped | 56%helped98 reports · medium confidence | 64%helped75 reports · medium confidence |
| Verdict | Mixed | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 215 / 637 | 479 / 1,597 |
| Mainly used for | ||
| Hormones % reporting improvement | 91% (44) | 98% (49) |
| Libido % reporting improvement | 91% (32) | 57% (7) |
| Mood % reporting improvement | 87% (30) | 0% (2) |
| Energy % reporting improvement | 92% (26) | 100% (5) |
| Anxiety % reporting improvement | 86% (7) | — |
| Common side effects | acne, vivid dreams, rage, virilization | fatigue, depression, low libido, headache |
| Typical dose reported | 25 mg / 1 hour before bed | Not listed |
Vaginal estrogen, vaginal DHEA, oral ospemifene, and vaginal moisturizers may improve some GSM symptoms in the short term. Few long-term data exist on efficacy, comparative effectiveness, tolerability, and safety of GSM treatments.
Ann Intern Med, 2024 ↗“DHEA, minimum 50 mg was a huge game changer for my wife. More energy, libido, dopamine/happy mood, concentration- everything.”
5 years of adjuvant tamoxifen safely reduces 15-year risks of breast cancer recurrence and death. ER status was the only recorded factor importantly predictive of the proportional reductions. Hence, the absolute risk reductions produced by tamoxifen depend on the absolute breast cancer risks (after any chemotherapy) without tamoxifen.
Lancet, 2011 ↗“This is now 2nd day on nolva and I swaer my balls are about back to normal. Energy is a bit better”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate