Agmatine vs Phenibut for mood
Short answer: For mood, users rate them about the same: 87% report improvement with Agmatine (122 reports) and 89% with Phenibut (131 reports).
Agmatine has 2 meta-analyses and 6 randomized trials on PubMed; Phenibut has 3 and 1.
Based on 594 reports about Agmatine and 740 about Phenibut. Not medical advice.
| Agmatine Supplement | Phenibut Substance | |
|---|---|---|
| User score | 55 | 50 |
| Verdict | Mostly positive | Mixed |
| Positive of reports that state an outcome | 68% | 44% |
| Reports | 594 | 740 |
| Research | BResearch: Moderate | BResearch: Moderate |
| Meta-analyses / RCTs | 2 / 6 | 3 / 1 |
| Mainly used for | ||
| Appetite % reporting improvement | 88% (8) | — |
| Focus % reporting improvement | 67% (24) | 69% (36) |
| Energy % reporting improvement | 65% (23) | 79% (28) |
| Sleep % reporting improvement | 79% (34) | 84% (64) |
| Anxiety % reporting improvement | 89% (93) | 87% (297) |
| Mood % reporting improvement | 87% (122) | 89% (131) |
| Memory % reporting improvement | 75% (4) | 50% (4) |
| Performance % reporting improvement | 96% (26) | 100% (5) |
| Recovery % reporting improvement | 100% (2) | — |
| Pain & inflammation % reporting improvement | 88% (16) | 50% (2) |
| Libido % reporting improvement | 100% (10) | 81% (16) |
| Hormones % reporting improvement | 50% (2) | — |
| Heart & lipids % reporting improvement | 80% (5) | — |
| Common side effects | drowsiness, vivid dreams, anxiety, stomach issues | withdrawal, addiction, tolerance, dependence |
| Typical dose reported | 1.5 g / before workout | every 3 days |
Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.
J Alzheimers Dis, 2019 ↗“Try using agimatine sulfate. when I took kratom for five years for pain management this is what I used to keep my tolerance in check and feeling like I've used it for the first time every time.”
Phenibut withdrawal appears to have a range of severity. It is important to recognize that patients undergoing phenibut abstinence may have progressive symptom worsening during early withdrawal. All published cases of abrupt phenibut abstinence were admitted inpatients for symptom management. Benzodiazepines or barbiturates with adjunctive baclofen appear to be the most commonly used drugs for moderate to severe withdrawal. Outpatient management via slow phenibut tapers with or without adjunctive gamma-aminobutyric acid agonist therapy may be successful. However, there is no standard treatment
Clin Toxicol (Phila), 2023 ↗“Phenibut every 3 days. Hands down most effective I've tried. Plus you wake up feeling amazing.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate