PlainPill

Agmatine vs Omega-3 for mood

Short answer: For mood, more users report improvement with Agmatine — 87% of 122 reports, versus 82% of 201 for Omega-3.

Agmatine has 2 meta-analyses and 6 randomized trials on PubMed; Omega-3 has 1,341 and 3,093.

Based on 594 reports about Agmatine and 1,959 about Omega-3. Not medical advice.

Agmatine
Supplement
Omega-3
Supplement
User score5547
Verdict
Mostly positive
Mostly positive
Positive
of reports that state an outcome
68%66%
Reports5941,959
ResearchBResearch: ModerateAResearch: Strong
Meta-analyses / RCTs2 / 61,341 / 3,093
Mainly used for
Weight loss
% reporting improvement
—100% (2)
Appetite
% reporting improvement
88% (8)—
Focus
% reporting improvement
67% (24)82% (129)
Energy
% reporting improvement
65% (23)74% (42)
Sleep
% reporting improvement
79% (34)79% (24)
Anxiety
% reporting improvement
89% (93)75% (69)
Mood
% reporting improvement
87% (122)82% (201)
Memory
% reporting improvement
75% (4)78% (50)
Performance
% reporting improvement
96% (26)88% (16)
Recovery
% reporting improvement
100% (2)90% (20)
Pain & inflammation
% reporting improvement
88% (16)91% (82)
Digestion
% reporting improvement
—22% (9)
Libido
% reporting improvement
100% (10)71% (14)
Hormones
% reporting improvement
50% (2)100% (2)
Blood sugar
% reporting improvement
—50% (2)
Heart & lipids
% reporting improvement
80% (5)76% (58)
Skin & hair
% reporting improvement
—89% (38)
Immunity
% reporting improvement
—60% (10)
Longevity
% reporting improvement
—86% (7)
Common side effectsdrowsiness, vivid dreams, anxiety, stomach issuesbrain fog, anxiety, depression, fatigue
Typical dose reported1.5 g / before workoutsparingly
Agmatine
Latest review conclusion

Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.

J Alzheimers Dis, 2019 ↗
What a user said
“Try using agimatine sulfate. when I took kratom for five years for pain management this is what I used to keep my tolerance in check and feeling like I've used it for the first time every time.”
Full Agmatine profile →
Omega-3
Latest review conclusion

For glycated hemoglobin, there was no significant effect in the meta-analysis. This systematic review with meta-analysis demonstrated that supplementation with omega-3 has protective effects on diabetes parameters.

Crit Rev Food Sci Nutr, 2022 ↗
What a user said
“I do supplement a lot of fish oil and vitamin A as retinyl palmitate though. It has really helped my depression, anxiety and ADHD and has enabled me to stop using more serious psychiatric drugs for those things.”
Full Omega-3 profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate