PlainPill

What people actually say

1,746 first-hand quotes, shortened but never edited — each links to the original discussion.

AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
RetatrutideMostly positive
“Drastically reduced appetite: At 5mg, I experienced near-total suppression of hunger and cravings. Steady, effortless fat loss: I didn't have to track macros obsessively or do extreme cardio.”
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RetatrutideMostly positive
“I’ve tried Reta and it melted fat away at 1mg - I really disliked the increased heart rate (and it was only 8bpm) and the nuking of my HRV.”
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RetatrutideMostly positive
“Once I started Reta at 2mg in January, it completely changed my mindset.”
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RetatrutideMostly positive
“I lost 115 lbs in the last year (260 → 145)...retatrutide seemed to finally address my insulin resistance.”
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KratomMixed
“Green or white Kratom powder. My productivity and overall mood have skyrocketed. I dose 4 grams once per day and it’s worked wonders.”
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KratomMixed
“Kratom/7Hydroxi makes me too sleepy and I feel dumb and slow on it.”
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KratomMixed
“kratom has been a Godsend and has really helped with getting me back on my feet. My preferred strain is Green Bali and found 2g to be my sweet spot in dose.”
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KratomMixed
“It keeps the depression, anxiety, suicidal and dark thoughts in check, but it also leaves my attention scattered, confused and makes me feel half-ADHD.”
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B ComplexMostly positive
“Adding a B complex has totally eliminated my depression lethargy brain fog insomnia and anxiety.”
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B ComplexMostly positive
“I only began the Stress-B Complex and Methyl-B12 within the past several months because my PCP suggested that B12 has shown to 'help with energy levels.' I haven't noticed a positive or negative change when taking them.”
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B ComplexMostly positive
“What helped me was a B complex vitamin plus magnesium plus vitamin D. Taken over 3mo.”
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B ComplexMostly positive
“Whenever I take my Mega B Complex my depression lifts almost instantly. Like everything seems brighter, happier, and my energy increases.”
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CBDMixed
“I take it for sleeping and anxiety and it works so well, even after five years. I haven't build up any tolerance.”
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CBDMixed
“CBD can really take the edge of my anxiety. It’s pretty amazing actually.”
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CBDMixed
“It works great and really opens up my lower back muscles when I lay in bed.”
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CBDMixed
“When I take it, I get this amazing and very introspective calm over me.”
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TirzepatideMostly positive
“Tirzepatide works so well! Do some research in the r/peptides subreddit and the r/tirzepatide subreddit. It's the most effective thing I've ever seen for appetite suppressant.”
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TirzepatideMostly positive
“I’m currently on tirzepatide 7.5mg (midway dose). Stacking sema because tirz isn’t helping it’s serious insomnia and sexual side effects.”
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TirzepatideMostly positive
“The Tirz was amazing and I dropped to a maintenance dose after I hit 195. When I stopped all peptides for two weeks prior to surgery, the Tirz didnt do anything when I restarted.”
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TirzepatideMostly positive
“I lost 33 in 4 weeks, 59 in 11 weeks on Tirzep + Test + Deca + Tesa while putting on muscle.”
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“I recently stopped taking Curcumin because of its affect on DHT and I was looking for an alternative measure to deal with inflammation as I feel it really helped with anxiety/depression.”
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“I find curcumin works just as well, if not better, than ibuprofen... I have sometimes experienced a little but of GI discomfort from taking it (gas, stomach pain)”
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“it greatly helped my inflammation symptoms after three weeks. I've tried reducing the dosage, but the symptoms start to gradually creep back.”
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“Ive been taking it for about a year now maybe a bit longer for anti inflamatory properties and i can tell a bit of a difference but the real stand out is my memory.”
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Green TeaMostly positive
“So I switched to green tea in the morning! Holy shit. The change has been incredible. I feel way less anxious, all depression thoughts have dissipated and I am proud of who I am.”
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Green TeaMostly positive
“It definitely increases fat burning. I have noticed that, as have multiple people in our office. However, it's not going to feel like caffeine.”
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Green TeaMostly positive
“Drinking green tea now opposed to coffee. My crash has improved immensely.”
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Green TeaMostly positive
“Five cups of Green Tea a day changed everything... I was able to focus more, socialize better and just have improved mood all day.”
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BoronMostly positive
“No one has mentioned Boron and Zinc. They make a very noticeable difference for me.”
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BoronMostly positive
“I’ve tried LJ100 tongkat ali (recently 200-300mg most days) and boron and neither of them seem to do much. Mild improvement at best.”
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BoronMostly positive
“I found it to be one of the most palpable supplements I've ever taken (3mg per day). I did feel all of the standard increased test effects (strength increase, more aggression in sports, better mood/libido)”
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BoronMostly positive
“Yes ive tried boron 10 mg a day, and it seemed to make it worse.”
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“But that pain gets significantly better when I take glycine, vitamin C and B6 together.”
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“daily supplementation of B6 completely changed my life in the early aughts...I definitely felt as though I had some deficits in executive function, picking up on social cues, etc.”
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“I take a multivitamin in the morning and B12/B6 around 2pm. The B6 helps to hit deep sleep.”
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“B6 toxicity is a thing for me - makes my feet burn and feel tender.”
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CiticolineMostly positive
“With standard NAC, Piracetam, and Choline I started to feel incredibly balanced, mood stabilized, better focus, and memory retention.”
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CiticolineMostly positive
“I started taking 250mg of CDP Choline with it as well. After a few days I remember it making me feel really down emotionally.”
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CiticolineMostly positive
“The above supplements have worked amazingly for my brain fog and motivation.”
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CiticolineMostly positive
“I believe this had led to excessive accumulation of acetylcholine (ACh) and subsequent symptoms (depression, low mood, anxiety, etc).”
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User reports — what people say about supplements — PlainPill