PlainPill

CBD

People mainly take CBD for anxiety, sleep, mood. Based on 220 first-hand reports and 286 meta-analyses & systematic reviews in the medical literature. Ranked #45 of 1,974 overall.

55
User score
Mixed
30% positive10% mixed11% negative50% unclear

Of reports that state an outcome, 59% are positive.

Clinical research
AStrong research base
286
meta-analyses
344
RCTs
8,541
papers

What CBD does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Psychiatry Res · 2024 · Meta-analysis / systematic review
Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis

Conclusion: In addition, this meta-analysis focuses on the efficacy of CBD in treating anxiety disorders such as generalized anxiety disorder (GAD), social anxiety disorder (SAD), and post-traumatic stress disorder (PTSD). However, caution should be exercised in interpreting our findings due to the limited size of the clinical sample, and additional trials ought to be carried out if deemed necessary.

PubMed 38924898 ↗
Int J Mol Sci · 2022 · Meta-analysis / systematic review
A 2022 Systematic Review and Meta-Analysis of Enriched Therapeutic Diets and Nutraceuticals in Canine and Feline Osteoarthritis

Conclusion: The efficacy assessment, associated to the level of quality of each trial, presented an evident clinical analgesic efficacy for omega-3-enriched diets, omega-3 supplements and cannabidiol (to a lesser degree). Our analyses showed a weak efficacy of collagen and a very marked non-effect of chondroitin-glucosamine nutraceuticals, which leads us to recommend that the latter products should no longer be recommended for pain management in canine and feline osteoarthritis.

PubMed 36142319 ↗
JAMA Psychiatry · 2019 · Meta-analysis / systematic review
Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis

Conclusion: Although individual-level risk remains moderate to low and results from this study should be confirmed in future adequately powered prospective studies, the high prevalence of adolescents consuming cannabis generates a large number of young people who could develop depression and suicidality attributable to cannabis. This is an important public health problem and concern, which should be properly addressed by health care policy.

PubMed 30758486 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

as neededas reported
30-60 mg; 54 mgafter dinner; before bed
25 mg2x daily
10 mg2x daily
600 mgas reported
25 mgdaily

Reported side effects

How often each side effect came up across all reports.

insomnia ×3brain fog ×2anxiety ×2headache ×1serotonin disruption ×1stomach issues ×1depression ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

Other options for anxiety

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate