What people actually say
2,084 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
Intermittent FastingMostly positive
“When I did intermittent fasting I got along OK and feel good if I drink enough water.”Source discussion ↗
Intermittent FastingMostly positive
“I also did intermittent fasting for the first 4 months and lost my first 50 lbs that way.”Source discussion ↗
Intermittent FastingMostly positive
“Have you tried intermittent fasting? That cleared up my brain fog when a lot of other things didn't help.”Source discussion ↗
ApigeninMixed
“L theanine 200mg, apigenin 50mg, mag theo, mag biglycinate makes me pee too much, GABA 600mg, 3g taurine. I have anxiety and panic disorder late into nights. And this has cured about 80% for me.”Source discussion ↗
ApigeninMixed
“once I stopped those supplements above...That included compounds such as...Apigenin, Quercetin, Fisetin...my liver tests came back to normal after 8 weeks.”Source discussion ↗
ApigeninMixed
“Three weeks of apigenin made a huge difference for me. I still take it to this day.”Source discussion ↗
ApigeninMixed
“Apigenin is my nr 2, it makes me so calm. It also helps my reaction time on humanbenchmark. I went from 220 ms to 170 ms.”Source discussion ↗
ResveratrolMixed
“started NMN and resveratrol which I can definitely feel a difference and see the sleep has gotten better since.”Source discussion ↗
ResveratrolMixed
“I feel more tired in my body, but mentally sharper. I am quite in tune to my blood sugar levels and it feels like they have dropped.”Source discussion ↗
ResveratrolMixed
“I've heard lots of horror stories about side effects of resveratrol, and it has such a complicated mechanism of action.”Source discussion ↗
ResveratrolMixed
“For me nadh, resveratrol and shilajit (sometimes with coq10) is my unbeatable energy stack.”Source discussion ↗
MemantineMixed
“I feel like I have all the positives of Adderall (focus, motivation, mood increase) without any noticeable downsides. No crash, no anxiety, no cardiac issues.”Source discussion ↗
MemantineMixed
“I woke up the next day feeling incredible! I felt light and buoyant...I felt light and buoyant. I had a strong desire to be outside in nature...my memory started to improve, my verbal fluency went up as well.”Source discussion ↗
MemantineMixed
“Used memantine to get off of kratom and it worked amazingly! But now I’m dependent on memantine.”Source discussion ↗
MemantineMixed
“I really like Memantine and Agmatine. Both works effective in terms of treating my anxiety and anhedonia. Unfortunately they both create too many side-effects. Memantine makes euphoric and wierd.”Source discussion ↗
NiacinMostly positive
“If you over methylate, niacin may also help you. Binds to free methyl groups... It's how I fixed my heart palpitations after taking methylsulfonymethan.”Source discussion ↗
NiacinMostly positive
“Been taking Niacin, but other than the flush, I've found it makes me feel kinda irritable after taking it and my stomach doesn't feel great.”Source discussion ↗
NiacinMostly positive
“I take niacin daily and have noticed big improvements in mental clarity / focus.”Source discussion ↗
NiacinMostly positive
“Had bad flushing w/ the niacin. Felt like I was on fire, massive blotching covered entire body.”Source discussion ↗
EphedrineMixed
“Ephedrine gives me tons of energy, makes me happy, positive, and talkative. It's an excellent pre-workout, though it doesn't suppress my appetite like it's supposed.”Source discussion ↗
EphedrineMixed
“This morning I had about 200mg of caffeine with ephedrine pre-workout because I didnt get the best sleep last night. I could not focus at ALL today at work.”Source discussion ↗
EphedrineMixed
“with 100mg caffeine, 200mg theanine, and 25mg ephedrine I still get pretty jittery. I've been taking 25 mg Ephedrine, 200 caffeine, 450 suntheanine, and 325 aspirin (not as a nootropic, to promote fat loss). Works pretty well for me.”Source discussion ↗
EphedrineMixed
“closest thing to adderall is ephedrine. I current switched from the ECA stack to the ECY stack (ephedrine, caffeine, Yohimbine) and it's working better for me.”Source discussion ↗
TadalafilMostly positive
“After a week of 2.5 mg twice a day, this is my favourite drug ever. My brain fog has gone...My mood is so much better, similar to an SSRI but without the flat feeling.”Source discussion ↗
TadalafilMostly positive
“I use it sporadically as a preworkout, 5mg before gym, gets a nice pump going - I always get a stuffy nose and that's about it from side effects that Ive noticed.”Source discussion ↗
TadalafilMostly positive
“It's probably the only drug I've ever taken that's improved my overall mood and impacted my mental health positively. People say it's because the improved blood flow in the brain.”Source discussion ↗
TadalafilMostly positive
“I take it for neuropathy. It’s solved about 95% of the tingling... Also fixed ED. I’m cutting the pills in half so it’s 2.5mg a day but works wonders.”Source discussion ↗
IronMostly positive
“I supplemented with sublingual b12 and iron and daily electrolytes and I'm feeling much better.”Source discussion ↗
IronMostly positive
“I have noticed quite a few supplements 'especially' herb based Iron supplements not working anymore, when before they used to.”Source discussion ↗
IronMostly positive
“Even though that is no where near 200ug, I'm noticing that my fatigue and mood is much better. My skin is clearer, and my period has become slightly less heavy.”Source discussion ↗
IronMostly positive
“I had something similar, my issue was low ferritin. I took iron supps and I’m feeling better than I have in years.”Source discussion ↗
PolygalaMostly positive
“I also take 100mg of Polygala 3x a day sublingual. It helps with recurring bad thoughts, and focus...helps with overall mood and sleep.”Source discussion ↗
PolygalaMostly positive
“I’ve found Polygala was much better for focus whereas agmatine was way better for my mood.”Source discussion ↗
PolygalaMostly positive
“Polygala alone (for me): quieter mind, slightly clearer thinking, but also slightly 'flattened' feeling...but in this combo it suddenly feels like the foundation that makes everything else work better.”Source discussion ↗
PolygalaMostly positive
“It immediately rid me of depression/anhedonia. My focus, energy, and memory all seem to have improved...I feel like the best version of myself.”Source discussion ↗
Milk ThistleMostly positive
“Adrafinil and milk thistle is my current best solution...Milk thistle helps for the hepatoxicity (as you know)”Source discussion ↗
Milk ThistleMostly positive
“Nothing much happened. I still had those problems after trying all that nootropics and supplements.”Source discussion ↗
Milk ThistleMostly positive
“Milk thistle can with some people cause Hypothyroidism... I had to quit taking I started gaining weight and my thyroid was swollen and hurt.”Source discussion ↗
Milk ThistleMostly positive
“I have improved taking milk thistle which helps my liver heal and to detoxify toxins.”Source discussion ↗
PregnenoloneMixed
“I know pregnenalone helped me with that anxiety... 25mg a day is wonderful.”Source discussion ↗