PlainPill
SupplementEnergyLibidoAnxiety

Yohimbine

People mainly take Yohimbine for energy, libido, anxiety. Based on 29 first-hand reports and 26 meta-analyses & systematic reviews in the medical literature. Ranked #497 of 1,974 overall.

Compare with…Alternatives for energy
27
User score
Mixed
21% positive14% mixed21% negative45% unclear

Of reports that state an outcome, 38% are positive.

Clinical research
AStrong research base
26
meta-analyses
152
RCTs
8,047
papers

What Yohimbine does, according to users

Of the people who reported each effect, the share who said it got better.

Energy67% of 6Libido100% of 5
4 more with fewer than 3 reports
Anxiety0% of 2Weight loss100% of 1Focus0% of 1Performance0% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

J Int Soc Sports Nutr · 2023 · Meta-analysis / systematic review
Effects of dietary supplements on athletic performance in elite soccer players: a systematic review

Conclusion: Finally, the available data does not support yohimbine supplementation or the use of Resurgex Plus® to improve athletic performance in elite soccer players. Still, more well-designed research with elite soccer players is needed to improve support and advice regarding the use of dietary supplements for athletic performance enhancement.

PubMed 37462346 ↗
BMJ Clin Evid · 2011 · Meta-analysis / systematic review
Erectile dysfunction

Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: alprostadil (intracavernosal, intraurethral, topical), cognitive behavioural therapy, ginseng, papaverine, papaverine plus phentolamine (bimix), papaverine plus phentolamine plus alprostadil (trimix), penile prostheses, phosphodiesterase inhibitors (sildenafil, tadalafil, vardenafil), psychosexual counselling, vacuum devices, and yohimbine.

PubMed 21711956 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

with fasted cardioas reported
15 mgdaily at 7-9am
7.5-15mgup to 3x daily, pre-cardio/fasted
before a fasted workoutas reported
10 mg2x daily
2 mg extracted (approx 75 mg bark)as reported

Reported side effects

How often each side effect came up across all reports.

anxiety ×5jitteriness ×3skin crawling ×1spontaneous erections ×1palpitations ×1overstimulation ×1nausea ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“this is required for things like CDP Choline, Yohimbine, Tongkat, Coleus”
Source discussion ↗
“Yohimbine effective but anxiety roulette if you overshoot.”
Source discussion ↗
“Yohamibine 8.6/10 (with fasted cardio) - works via a2 receptors, removes the breaks and basically releases fatty acids into the blood to be burned off, in real-time you are actively burning off exclusively fat from this,”
Source discussion ↗
“I'm doing 16/8 first meal at 2pm, but around 7-9am I do cardio fasted with 15mg Yohimbine taken 30 mins prior. In theory, this should help my body use more fat, I've not tried this approach for long so can't prove anythi”
Source discussion ↗
“Yohimbine certainly gets my blood flowing, but can also increase my anxiety and heart rate to unbearable levels.”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate