Tesamorelin vs Yohimbine for weight loss
Short answer: For weight loss, users rate them about the same: 95% report improvement with Tesamorelin (82 reports) and 97% with Yohimbine (35 reports).
Tesamorelin has 3 meta-analyses and 21 randomized trials on PubMed; Yohimbine has 26 and 152.
Based on 265 reports about Tesamorelin and 202 about Yohimbine. Not medical advice.
| Tesamorelin Peptide | Yohimbine Supplement | |
|---|---|---|
| Users say it helped | 58%helped119 reports · high confidence | 43%helped93 reports · medium confidence |
| Verdict | Mixed | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 3 / 21 | 26 / 152 |
| Mainly used for | ||
| Weight loss % reporting improvement | 95% (82) | 97% (35) |
| Performance % reporting improvement | 88% (25) | 62% (8) |
| Libido % reporting improvement | — | 93% (29) |
| Energy % reporting improvement | 100% (5) | 91% (22) |
| Sleep % reporting improvement | 70% (20) | — |
| Common side effects | water retention, allergic reaction, anaphylaxis, swelling | anxiety, jitteriness, sweating, nausea |
| Typical dose reported | Not listed | 5 mg / pre cardio |
However, limited data on long-term safety, optimal dosing strategies, and durability of treatment effects warrant caution. Future research should evaluate extended treatment duration, dose-response relationships, and patient-reported outcomes to establish comprehensive clinical utility.
J Int Assoc Provid AIDS Care, 2026 ↗“I also added Tesamorelin 2 months in due to the harder time sleeping on Retatrutide and wanting to accelerate the burn of my visceral fats (2mg 5x a week). Worked like magic for me.”
Finally, the available data does not support yohimbine supplementation or the use of Resurgex Plus® to improve athletic performance in elite soccer players. Still, more well-designed research with elite soccer players is needed to improve support and advice regarding the use of dietary supplements for athletic performance enhancement.
J Int Soc Sports Nutr, 2023 ↗“what I take atm is caffeine, yohimbine, huperzine a, and taurine. Those items for me give me more than enough energy.”
Related comparisons
Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate