Conclusion: In this systematic review and network meta-analysis, mirtazapine, biperiden, and vitamin B6 were associated with the greatest efficacy for AIA, with vitamin B6 having the best efficacy and tolerance profile. Trazodone, mianserin, and propranolol appeared as effective alternatives with slightly less favorable efficacy and tolerance profiles. These findings should assist prescribers in selecting an appropriate medication for treating AIA.
PubMed 38451521 ↗Propranolol
People mainly take Propranolol for anxiety, sleep, focus. Based on 55 first-hand reports and 268 meta-analyses & systematic reviews in the medical literature. Ranked #125 of 1,974 overall.
Of reports that state an outcome, 80% are positive.
What Propranolol does, according to users
Of the people who reported each effect, the share who said it got better.
2 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Also, no evidence was found for effects of propranolol on PTSD symptom severity through inhibition of memory reconsolidation. In conclusion, the quality of evidence for the efficacy of propranolol at present is insufficient to support the routine use of propranolol in the treatment of any of the anxiety disorders.
PubMed 26487439 ↗Conclusion: beta Blockers are effective in long term secondary prevention after myocardial infarction, but they are underused in such cases and lead to avoidable mortality and morbidity.
PubMed 10381708 ↗Conclusion: Beta-blockers are increasingly prescribed for anxiety, yet there is a lack of robust evidence of effectiveness. There is a need to understand when and why practitioners are using these drugs, and to undertake a large RCT to provide definitive evidence of whether beta-blockers are an effective and safe treatment for anxiety.
PubMed 39271062 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“propranolol (as needed)”
“Beta blockers like propranolol can ease the physical issues of sweating, blushing, shaking etc. Doctors will sometimes prescribe them for public speaking.”
“I've personally replaced Phenibut with that for public speaking / interviews etc”
“propranolol. stage performers often take it to curb stagefright.”
“Personally, I highly recommend propranolol, but it is definitely not a nootropic.”
Top discussions (5)
- Most effective and profoundly noticeable substance for Social Anxiety ↗
- I've had enough man. How do I stop physical anxiety? ↗
- Most effective and profoundly noticeable psychotropic substance for reducing Social Anxiety? ↗
- Propranolol made every other anti-anxiety supplement I’ve tried look like a placebo ↗
- Supplementation guide to stimulants ↗
Other options for anxiety
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate