PlainPill

Aniracetam vs Skullcap for anxiety

Short answer: For anxiety, more users report improvement with Skullcap — 100% of 31 reports, versus 92% of 191 for Aniracetam.

Aniracetam has 1 meta-analyses and 9 randomized trials on PubMed; Skullcap has 5 and 3.

Based on 899 reports about Aniracetam and 97 about Skullcap. Not medical advice.

Aniracetam
Supplement
Skullcap
Supplement
Users say it helped60%helped405 reports · high confidence81%helped46 reports · medium confidence
Verdict
Mostly positive
Mostly positive
ResearchBResearch: ModerateBResearch: Moderate
Meta-analyses / RCTs1 / 95 / 3
Mainly used for
Anxiety
% reporting improvement
92% (191)100% (31)
Focus
% reporting improvement
85% (200)—
Mood
% reporting improvement
87% (100)67% (3)
Memory
% reporting improvement
85% (55)—
Energy
% reporting improvement
64% (22)100% (2)
Common side effectsdrowsiness, irritability, fatigue, headachedysphoria, drowsiness, liver damage, unusual next
Typical dose reported750 mg2-4 g / PRN
Aniracetam
Latest review conclusion

The most effective intervention for dementia available is symptomatic treatment for vascular dementia. Antipsychotic treatment for dementia alleviates cognitive dysfunction less effectively than does symptomatic treatment. Alternative therapies are also effective at present. Further research on causes and very early diagnosis of Alzheimer disease is warranted.

Psychopharmacology (Berl), 2018 ↗
What a user said
“Aniracetam: Anecdotally I could feel instantaneous mental improvement within 2-3 days... The most significant improvement was attention... organization, and confidence.”
Full Aniracetam profile →
Skullcap
Latest review conclusion

Besides, no severe adverse effects was identified by CHM. CHM, especially classical Chinese herbal formulas, could be used as potential candidates for COVID-19 in this battle.

Pharmacol Res, 2020 ↗
What a user said
“St. John's Wort, Passion Flower, Hops, and Skullcap. My sleep improved with those.”
Full Skullcap profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate