Lithium Orotate vs Skullcap for anxiety
Short answer: For anxiety, users rate them about the same: 98% report improvement with Lithium Orotate (80 reports) and 100% with Skullcap (31 reports).
Lithium Orotate has 581 meta-analyses and 979 randomized trials on PubMed; Skullcap has 5 and 3.
Based on 307 reports about Lithium Orotate and 97 about Skullcap. Not medical advice.
| Lithium Orotate Supplement | Skullcap Supplement | |
|---|---|---|
| Users say it helped | 76%helped138 reports · high confidence | 81%helped46 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 581 / 979 | 5 / 3 |
| Mainly used for | ||
| Anxiety % reporting improvement | 98% (80) | 100% (31) |
| Mood % reporting improvement | 92% (108) | 67% (3) |
| Sleep % reporting improvement | 100% (16) | 100% (12) |
| Focus % reporting improvement | 81% (16) | — |
| Common side effects | brain fog, emotional blunting, sexual dysfunction, drowsiness | dysphoria, drowsiness, liver damage, unusual next |
| Typical dose reported | 1-2 tablets | 2-4 g / PRN |
Although it is yet to be determined which is more effective between lithium or lecanemab or donanemab, lithium may be more effective than aducanumab. Aducanumab, lecanemab and donanemab do not appear to differ in their effectiveness on cognitive function. Low-dose lithium may be safer than aducanumab, lecanemab and donanemab.
Ageing Res Rev, 2024 ↗“The lithium is absolutely curbing my mania... My social anxiety is 100% gone when I take lithium orotate.”
Besides, no severe adverse effects was identified by CHM. CHM, especially classical Chinese herbal formulas, could be used as potential candidates for COVID-19 in this battle.
Pharmacol Res, 2020 ↗“St. John's Wort, Passion Flower, Hops, and Skullcap. My sleep improved with those.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate