Hcg vs Pregnenolone for hormones
Short answer: For hormones, more users report improvement with Hcg — 85% of 41 reports, versus 79% of 24 for Pregnenolone.
Hcg has 324 meta-analyses and 972 randomized trials on PubMed; Pregnenolone has 12 and 36.
Based on 190 reports about Hcg and 246 about Pregnenolone. Not medical advice.
| Hcg Medication | Pregnenolone Supplement | |
|---|---|---|
| Users say it helped | 64%helped53 reports · medium confidence | 53%helped79 reports · medium confidence |
| Verdict | Mostly positive | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 324 / 972 | 12 / 36 |
| Mainly used for | ||
| Hormones % reporting improvement | 85% (41) | 79% (24) |
| Mood % reporting improvement | 100% (3) | 94% (31) |
| Anxiety % reporting improvement | — | 77% (30) |
| Libido % reporting improvement | 93% (14) | 67% (15) |
| Energy % reporting improvement | 100% (3) | 86% (21) |
| Common side effects | suppression, high estrogen, leg seizures, acne | hair loss, demotivation, jitteriness, androgenic symptoms |
| Typical dose reported | Not listed | 5 mg / 2x daily |
In people with type 2 diabetes, the cardiovascular and kidney benefits of GLP-1 receptor agonists are consistent regardless of SGLT2 inhibitor use.
Circulation, 2024 ↗“hcg.. although it may raise estrogen too much. worked great for me, strength increases, amazing libido, lost some fat.”
Women with anorexia nervosa have higher cortisol levels and lower DHEA-S and testosterone levels compared to women without anorexia nervosa. This finding is important to consider when evaluating low-weight women for disorders involving the adrenal axis, especially Cushing's syndrome.
Eur J Endocrinol, 2023 ↗“I know pregnenalone helped me with that anxiety... 25mg a day is wonderful.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate