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Pregnenolone side effects

Across 246 first-hand reports, people mentioned a side effect 12 times (about 5 per 100 reports). The most common: hair loss, demotivation, jitteriness. User reports show what people notice — they can't tell you whether Pregnenolone is safe for you.

Reported side effects

hair loss3
demotivation2
jitteriness2
androgenic symptoms1
withdrawal1
rage1
irritability1
decreased libido1

What got worse for some people

In their own words

“Now it's like 90% fixed by pregnenolone. However, I been taking around 10 to 20 mg this is the sweet spot for me if I take anymore I get the opposite reaction such as more fatigue and tiredness.”
MixedRead the discussion ↗
“I've never felt more comfortable in my own skin, more calm, or stable. Things just feel right. But: Definitely not a keeper for me. Either no effect or I get more jittery/anxious.”
MixedRead the discussion ↗
“I experienced heart palpitations as I never have before... Now I'm done to 1mg and don't feel a damn thing, good or bad.”
MixedRead the discussion ↗
“I have been taking it for a few months. It *seems* to have helped with weight control and metabolism/energy.”
MixedRead the discussion ↗
“I've taken it for 5 days so far at 5mg single dose per day. Maybe it's early days but I've noticed I feel slightly more stimulated and more anxious. Definitely zero calming effects so far.”
MixedRead the discussion ↗
“Could pregnenolone be giving me that more relaxed and less aggressive/driven feeling? I'm thinking about taking it off the stack.”
MixedRead the discussion ↗

Is Pregnenolone safe? What the research covers

AResearch: Strong12 meta-analyses · 36 randomized trials on PubMed
J Ethnopharmacol · 2017
A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisum

Conclusion: In this paper, we have reviewed various researches conducted on N. incisum especially in areas of its ethnopharmacological use, phytochemicals, pharmacology and developed analytical methods. This herb has been used over the years in treating headache, rheumatoid arthritis, cold, diaphoretic etc, prompting many types of research into identifying which compounds are responsible for these activities and their mechanism of action. More research is needed in the area of pharmacokinetics and toxicology to give further information on the clinical use and control the quality of the herb.

Pregnenolone side effects: what 246 users report — PlainPill