Conclusion: In this paper, we have reviewed various researches conducted on N. incisum especially in areas of its ethnopharmacological use, phytochemicals, pharmacology and developed analytical methods. This herb has been used over the years in treating headache, rheumatoid arthritis, cold, diaphoretic etc, prompting many types of research into identifying which compounds are responsible for these activities and their mechanism of action. More research is needed in the area of pharmacokinetics and toxicology to give further information on the clinical use and control the quality of the herb.
Pregnenolone side effects
Across 246 first-hand reports, people mentioned a side effect 12 times (about 5 per 100 reports). The most common: hair loss, demotivation, jitteriness. User reports show what people notice — they can't tell you whether Pregnenolone is safe for you.
Reported side effects
hair loss3
demotivation2
jitteriness2
androgenic symptoms1
withdrawal1
rage1
irritability1
decreased libido1
What got worse for some people
In their own words
“Now it's like 90% fixed by pregnenolone. However, I been taking around 10 to 20 mg this is the sweet spot for me if I take anymore I get the opposite reaction such as more fatigue and tiredness.”
“I've never felt more comfortable in my own skin, more calm, or stable. Things just feel right. But: Definitely not a keeper for me. Either no effect or I get more jittery/anxious.”
“I experienced heart palpitations as I never have before... Now I'm done to 1mg and don't feel a damn thing, good or bad.”
“I have been taking it for a few months. It *seems* to have helped with weight control and metabolism/energy.”
“I've taken it for 5 days so far at 5mg single dose per day. Maybe it's early days but I've noticed I feel slightly more stimulated and more anxious. Definitely zero calming effects so far.”
“Could pregnenolone be giving me that more relaxed and less aggressive/driven feeling? I'm thinking about taking it off the stack.”
Is Pregnenolone safe? What the research covers
AResearch: Strong12 meta-analyses · 36 randomized trials on PubMed
J Ethnopharmacol · 2017
A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisumSchizophr Res · 2015
Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative reviewConclusion: Estrogens and SERMs could be effective augmentation strategies in the treatment of women with schizophrenia, although potential side effects, partially associated with longer duration use, should be taken into account. Future trials are needed to study long-term effects and effects on cognition.