Prednisone vs Pregnenolone for pain & inflammation
Short answer: For pain & inflammation, users rate them about the same: 100% report improvement with Prednisone (5 reports) and 100% with Pregnenolone (4 reports).
Prednisone has 608 meta-analyses and 3,012 randomized trials on PubMed; Pregnenolone has 12 and 36.
Based on 15 reports about Prednisone and 246 about Pregnenolone. Not medical advice.
| Prednisone Medication | Pregnenolone Supplement | |
|---|---|---|
| Users say it helped | 62%helped13 reports · few reports | 53%helped79 reports · medium confidence |
| Verdict | Mostly positive | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 608 / 3,012 | 12 / 36 |
| Mainly used for | ||
| Mood % reporting improvement | 100% (4) | 94% (31) |
| Anxiety % reporting improvement | — | 77% (30) |
| Energy % reporting improvement | 100% (4) | 86% (21) |
| Hormones % reporting improvement | — | 79% (24) |
| Focus % reporting improvement | — | 93% (15) |
| Common side effects | mania, side effects, agitation, insomnia | hair loss, demotivation, jitteriness, androgenic symptoms |
| Typical dose reported | Not listed | 5 mg / 2x daily |
The symptoms and unique findings that make up RS(3)PE appear to represent a steroid-responsive disease that may be a harbinger of an underlying malignancy. More study is needed to understand the molecular origins of RS(3)PE in order to determine whether it is a separate disease process. Patients with concurrent cancer tend to have more severe presentations and higher rates of recurrence.
Clin Exp Rheumatol, 2016 ↗“It was probably the best I have ever felt because I actually had energy for once.”
Women with anorexia nervosa have higher cortisol levels and lower DHEA-S and testosterone levels compared to women without anorexia nervosa. This finding is important to consider when evaluating low-weight women for disorders involving the adrenal axis, especially Cushing's syndrome.
Eur J Endocrinol, 2023 ↗“I know pregnenalone helped me with that anxiety... 25mg a day is wonderful.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate