Hrt vs Pregnenolone for energy
Short answer: For energy, more users report improvement with Hrt — 100% of 5 reports, versus 86% of 21 for Pregnenolone.
Hrt has 284 meta-analyses and 850 randomized trials on PubMed; Pregnenolone has 12 and 36.
Based on 15 reports about Hrt and 246 about Pregnenolone. Not medical advice.
| Hrt Medication | Pregnenolone Supplement | |
|---|---|---|
| Users say it helped | 100%helped10 reports · few reports | 53%helped79 reports · medium confidence |
| Verdict | Mostly positive | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 284 / 850 | 12 / 36 |
| Mainly used for | ||
| Mood % reporting improvement | — | 94% (31) |
| Anxiety % reporting improvement | — | 77% (30) |
| Energy % reporting improvement | 100% (5) | 86% (21) |
| Hormones % reporting improvement | 100% (2) | 79% (24) |
| Focus % reporting improvement | 100% (2) | 93% (15) |
| Common side effects | None reported | hair loss, demotivation, jitteriness, androgenic symptoms |
| Typical dose reported | Not listed | 5 mg / 2x daily |
Use of HRT was associated with a detrimental prognostic effect in BC survivors, particularly in those with hormone receptor-positive disease. Alternative interventions to mitigate menopause-related symptoms should be proposed.
Breast Cancer Res Treat, 2022 ↗“I was on HRT which helped and after a year they messed up my perception and I’ve had a 9 day gap.”
Women with anorexia nervosa have higher cortisol levels and lower DHEA-S and testosterone levels compared to women without anorexia nervosa. This finding is important to consider when evaluating low-weight women for disorders involving the adrenal axis, especially Cushing's syndrome.
Eur J Endocrinol, 2023 ↗“I know pregnenalone helped me with that anxiety... 25mg a day is wonderful.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate