Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: applied behavioural analysis; auditory integration training; Autism Preschool Programme; casein-free diet; chelation; Child's Talk programme; cognitive behavioural therapy; digestive enzymes; EarlyBird programme; facilitated communication; Floortime therapy; gluten-free diet; immunoglobulins; melatonin; memantine; methylphenidate; More Than Words programme; music therapy; olanzapine; omega-3 fish oil; picture exchange communication system; Portage scheme; probiotics; relati
PubMed 21729335 ↗Digestive Enzymes
People mainly take Digestive Enzymes for digestion, sleep, pain & inflammation. Based on 35 first-hand reports and 18 meta-analyses & systematic reviews in the medical literature. Ranked #311 of 1,974 overall.
Of reports that state an outcome, 72% are positive.
What Digestive Enzymes does, according to users
Of the people who reported each effect, the share who said it got better.
3 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: applied behavioural analysis, Autism Pre-school Programme, Child's Talk, More than words, Picture Exchange Communication System, TEACCH, Early Bird Programme, Floor time, Portage scheme, relationship development interventions, social skills training, social stories, Son-Rise, digestive enzymes, gluten free diet, casein free diet, omega-3 fish oil, probiotics, vitamin A, vitamin B6 (pyridoxine) plus magnesium, vitamin C, methylphenidate, risperidone, selective serotonin reup
PubMed 19450315 ↗Conclusion: Taken together, the papers on which the current review is based, suggest that dietary fiber has the potential to change the gut microbiota and alter metabolic regulation. However, due to the heterogeneity of the studies, a firm conclusion describing the causal relationship between gut microbiota and metabolic regulation remains elusive.
PubMed 32210176 ↗Conclusion: The systematic review demonstrates that the IM plays a major role in the breakdown and transformation of the dietary substrates examined. However, recent human data are limited with the exception of data from studies examining fibres and polyphenols. Results observed in relation with dietary substrates were not always consistent or coherent across studies and methodological limitations and differences in IM analyses made comparisons difficult. Moreover, non-digestible components likely to reach the colon are often not well defined or characterised in studies making comparisons between studies
PubMed 29086061 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“Digestive enzymes probably won't make much difference.”
“tablets with digestive enzymes to help with the digestion, especially if there’s a lot of fat.”
“Digestive enzymes with meals”
“I have been trying digestive enzymes, probiotics, and activated charcoal to varying degrees of success”
“Digestive Enzymes - 1 Super enzyme capsule”
Top discussions (5)
- Day 55 Only eating Supplements- Lost 40lbs and Plateaued ↗
- Best way to increase deep sleep? ↗
- Digestive enzymes for better sleep ↗
- Disappointed. I have 40-50 different nootropics at home. Caffeine & L-Theanine seem to be the only ones that work. ↗
- Update: Guide to Healing Your Gut - Thoughts, Dietary Suggestions, Supplemental Alternatives, and Depression. ↗
Other options for digestion
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate