PlainPill

Digestive Enzymes vs Glutamine for digestion

Short answer: For digestion, more users report improvement with Glutamine — 100% of 11 reports, versus 90% of 21 for Digestive Enzymes.

Digestive Enzymes has 18 meta-analyses and 31 randomized trials on PubMed; Glutamine has 361 and 787.

Based on 62 reports about Digestive Enzymes and 146 about Glutamine. Not medical advice.

Digestive Enzymes
Supplement
Glutamine
Supplement
Users say it helped72%helped27 reports · medium confidence37%helped55 reports · medium confidence
Verdict
Mostly positive
Mixed
ResearchAResearch: StrongAResearch: Strong
Meta-analyses / RCTs18 / 31361 / 787
Mainly used for
Digestion
% reporting improvement
90% (21)100% (11)
Recovery
% reporting improvement
—100% (11)
Immunity
% reporting improvement
—100% (6)
Performance
% reporting improvement
—0% (5)
Common side effectsstomach issuesurine odor, headache, vivid dreams, stomach issues
Typical dose reported1 capsule / 3x daily5 mg / before bed
Digestive Enzymes
Latest review conclusion

In this systematic review we present information relating to the effectiveness and safety of the following interventions: applied behavioural analysis; auditory integration training; Autism Preschool Programme; casein-free diet; chelation; Child's Talk programme; cognitive behavioural therapy; digestive enzymes; EarlyBird programme; facilitated communication; Floortime therapy; gluten-free diet; immunoglobulins; melatonin; memantine; methylphenidate; More Than Words programme; music therapy; olanzapine; omega-3 fish oil; picture exchange communication system; Portage scheme; probiotics; relati

BMJ Clin Evid, 2010 ↗
What a user said
“Digestive enzymes before every meal. I take NOW FOODS Super Enzymes. ... Noticed I was calm af. Stopped taking them. Anxiety came back in about three days.”
Full Digestive Enzymes profile →
Glutamine
Latest review conclusion

In studies using high-throughput metabolomics, several blood amino acids appear to be consistently associated with the risk of developing type 2 diabetes.

Diabetes Care, 2016 ↗
What a user said
“amino acids L carnitine and glutamine made a difference in my skin.”
Full Glutamine profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate