PlainPill

L-Glutamine

People mainly take L-Glutamine for digestion, anxiety, mood. Based on 86 first-hand reports and 19 meta-analyses & systematic reviews in the medical literature. Ranked #329 of 2,750 overall.

38
User score
Mostly positive
31% positive8% mixed10% negative50% unclear

Of reports that state an outcome, 63% are positive.

Clinical research
AStrong research base
19
meta-analyses
117
RCTs
3,603
papers

What L-Glutamine does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Acta Odontol Latinoam · 2023 · Meta-analysis / systematic review
Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review

Conclusion: Dentoxol mouthwashes, Plantago major extract, thyme honey extract, zinc oxide paste, vitamin B complex combined with GeneTime, and the consumption of L-glutamine are effective in diminishing the severity of OM. Pain intensity was lower with doxepin mouthwashes and diphenhydramine-lidocaine-antacid mouthwashes.

PubMed 37314054 ↗
Physiol Rep · 2017 · Meta-analysis / systematic review
Comparative effects of intraduodenal amino acid infusions on food intake and gut hormone release in healthy males

Conclusion: The greater satiating efficacy of LEU versus PHE was significantly dissociated from the effects of these AAs on PYY, while the greater satiating potency of TRP versus PHE was significantly dissociated from the effects of these AAs on insulin and glucagon. In contrast, ghrelin and CCK, and potentially other mechanisms, including central sensing of individual AAs, appear to be stronger candidate mechanisms for the relative satiating effects obtained.

PubMed 29138359 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

5 gas reported
5 gthroughout the day
2 gas reported
after last meal of dayas reported
10-15 gas reported
300 mgas reported

Reported side effects

How often each side effect came up across all reports.

anxiety ×2stomach issues ×1weird feeling ×1glutamate spikes ×1insomnia ×1jitteriness ×1panic attack ×1dizziness ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Ashwaghanda, Phosphatidylserine, L-Glutamine, Probiotics, CurcuBrain (Longvida) etc. most of them didn't provide any meaningful and noticeable benefits”
Source discussion ↗
“Some natural L-glutamin form along with Vitamin U”
Source discussion ↗
“20g L-Glutamine (5g per serving during the day)”
Source discussion ↗
“Feeling a lot better after taking a bunch of glutamine today, probably 10-15g.”
Source discussion ↗
“L-glutamine”
Source discussion ↗
Top discussions (5)

L-Glutamine compared

Other options for digestion

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate