Best for sleep

281 options people report for falling and staying asleep, sleep quality, ranked by the share of users who say it improved — weighted by how many reports there are.

Weight loss Appetite Focus Energy Sleep Anxiety Mood Memory Performance Recovery Pain & inflammation Digestion Libido Hormones Blood sugar Heart & lipids Skin & hair Immunity Longevity

Type:All Supplements Peptides Medications Substances Lifestyle Methods SARMs OtherResearch-backed only

40 results

155

TrazodoneMedication

Sleep Libido Mood

91% report better Sleep

22 reports

MixedAResearch: Strong

234

ProgesteroneMedication

Sleep

100% report better Sleep

10 reports

Mostly positiveAResearch: Strong

328

BenadrylMedication

Sleep Anxiety Focus

92% report better Sleep

12 reports

MixedBResearch: Moderate

431

GabapentinMedication

Anxiety Sleep Mood

90% report better Sleep

10 reports

MixedAResearch: Strong

525

HydroxyzineMedication

Sleep Anxiety

100% report better Sleep

7 reports

MixedAResearch: Strong

630

MirtazapineMedication

Sleep Mood Anxiety

100% report better Sleep

6 reports

MixedAResearch: Strong

737

AmbienMedication

Sleep

70% report better Sleep

10 reports

MixedCResearch: Limited

870

TirzepatideMedication

Weight loss Appetite Mood

83% report better Sleep

6 reports

Mostly positiveAResearch: Strong

945

TestosteroneMedication

Performance Mood Libido

83% report better Sleep

6 reports

Mostly positiveAResearch: Strong

1032

UnisomMedication

Sleep

80% report better Sleep

5 reports

Mostly positiveDResearch: None

1162

TadalafilMedication

Libido Performance Mood

100% report better Sleep

3 reports

Mostly positiveAResearch: Strong

1257

GuanfacineMedication

Focus Anxiety Sleep

100% report better Sleep

3 reports

Mostly positiveAResearch: Strong

1350

XanaxMedication

Anxiety Sleep Focus

100% report better Sleep

3 reports

MixedBResearch: Moderate

1439

HrtMedication

Energy Sleep

100% report better Sleep

3 reports

Mostly positiveAResearch: Strong

1519

AgomelatineMedication

Sleep Energy

100% report better Sleep

3 reports

Mostly positiveAResearch: Strong

1614

QuetiapineMedication

Sleep

100% report better Sleep

3 reports

Mostly negativeAResearch: Strong

176

ZopicloneMedication

Sleep Anxiety

100% report better Sleep

3 reports

MixedResearch pending

1847

TRTMedication

Mood Energy Hormones

100% report better Sleep

2 reports

Mostly positiveAResearch: Strong

1935

IbuprofenMedication

Pain & inflammation Memory Focus

100% report better Sleep

2 reports

MixedAResearch: Strong

2034

BaclofenMedication

Anxiety Mood Sleep

100% report better Sleep

2 reports

Mostly positiveAResearch: Strong

2125

MetforminMedication

Performance Blood sugar Energy

100% report better Sleep

2 reports

MixedAResearch: Strong

2221

SeroquelMedication

Sleep Mood

100% report better Sleep

2 reports

Mostly positiveResearch pending

2319

AntihistaminesMedication

Sleep Focus Anxiety

100% report better Sleep

2 reports

MixedAResearch: Strong

2415

KlonopinMedication

Anxiety Sleep Memory

100% report better Sleep

2 reports

Mostly negativeDResearch: None

2514

OlanzapineMedication

Anxiety Sleep Focus

100% report better Sleep

2 reports

MixedResearch pending

2614

PrazosinMedication

Sleep

100% report better Sleep

2 reports

Mostly positiveResearch pending

275

GaboxadolMedication

Sleep

100% report better Sleep

2 reports

MixedResearch pending

2821

DiphenhydramineMedication

Sleep

60% report better Sleep

5 reports

Mostly negativeAResearch: Strong

2946

ModafinilMedication

Focus Energy Mood

21% report better Sleep

39 reports

MixedAResearch: Strong

3032

MethylphenidateMedication

Focus Mood Anxiety

40% report better Sleep

5 reports

MixedAResearch: Strong

3165

SemaglutideMedication

Weight loss Appetite Energy

50% report better Sleep

2 reports

Mostly positiveAResearch: Strong

3214

DiazepamMedication

Anxiety Sleep

50% report better Sleep

2 reports

Mostly negativeAResearch: Strong

3349

PropranololMedication

Anxiety Sleep Focus

25% report better Sleep

4 reports

Mostly positiveAResearch: Strong

3438

BupropionMedication

Mood Energy Focus

25% report better Sleep

4 reports

MixedAResearch: Strong

3529

RitalinMedication

Focus Mood Anxiety

25% report better Sleep

4 reports

MixedAResearch: Strong

3636

VyvanseMedication

Focus Mood Energy

14% report better Sleep

7 reports

MixedBResearch: Moderate

3753

AdderallMedication

Focus Mood Energy

8% report better Sleep

12 reports

MixedAResearch: Strong

3845

AdrafinilMedication

Focus Energy Mood

0% report better Sleep

2 reports

MixedDResearch: None

3925

Adderall XrMedication

Focus Mood Energy

0% report better Sleep

2 reports

MixedBResearch: Moderate

405

ZquilMedication

Sleep Anxiety

0% report better Sleep

2 reports

Mostly negativeResearch pending

Minimum 2 reports per entry. Information only — not medical advice. How rankings work