PlainPill

Inositol

People mainly take Inositol for anxiety, mood, sleep. Based on 123 first-hand reports and 209 meta-analyses & systematic reviews in the medical literature. Ranked #23 of 1,974 overall.

60
User score
Mostly positive
39% positive6% mixed9% negative46% unclear

Of reports that state an outcome, 72% are positive.

Clinical research
AStrong research base
209
meta-analyses
248
RCTs
43,556
papers

What Inositol does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

J Clin Endocrinol Metab · 2024 · Meta-analysis / systematic review
Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines

Conclusion: The evidence supporting the use of inositol in the management of PCOS is limited and inconclusive. Clinicians and their patients should consider the uncertainty of the evidence together with individual values and preferences when engaging in shared decision-making regarding the use of inositol for PCOS.

PubMed 38163998 ↗
Front Endocrinol (Lausanne) · 2024 · Meta-analysis / systematic review
Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis

Conclusion: During a 6-month treatment, the use of Myo-inositol, Vitamin D alone, and the combination of selenium, and Myo-inositol did not effectively reduce TPOAb (Myo-inositol: SMD:-1.94, 95% CI: -6.75, 2.87; Vitamin D: SMD: -2.54, 95% CI: -6.51,1.42; Se+Myo-inositol: SMD: -3.01, 95% CI: -8.96,2.93) or TgAb (Myo-inositol: SMD:-2.02, 95% CI: -6.52, 2.48; Vitamin D: SMD: -2.73, 95% CI: -6.44,0.98; Se+Myo-inositol: SMD: -3.64, 95% CI: -9.20,1.92) levels. Therefore, we recommend that patients with HT(Hashimoto's Thyroiditis) be given an appropriate amount of selenium as an auxiliary treatment during standa

PubMed 39698034 ↗
Nutr Neurosci · 2023 · Meta-analysis / systematic review
Nutrition and bipolar disorder: a systematic review

Conclusion: Taken together, these preliminary findings suggest that dietetic approaches might be included as part of BD treatment. Also considering the high risk of metabolic disorders in individuals with BD, they should be encouraged to choose healthy dietary lifestyles, including daily intake of fruits, vegetables, seafood and whole grains.

PubMed 35608150 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

10-25 gas reported
2 g myo-inositol + 50 mg d-chiro2x daily
4-6 gdaily
2 gbefore bed as needed
2-4 gdaily
for a few monthsas reported

Reported side effects

How often each side effect came up across all reports.

brain fog ×3reduced attractiveness ×1agitation ×1reading comprehension ×1verbal fluency ×1stomach issues ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Inositol is powerful. It's just a supplement not a drug you can purchase online.”
Source discussion ↗
“Adding in inositol before bed, prebiotic fiber or potentially a spoonful of honey could allow you to sleep without that crash.”
Source discussion ↗
“Inositol and ashwagandha both helped me the most with that problem.”
Source discussion ↗
“Aniracetam, DMAE, choline, inositol, rhodiola, coffee, tea”
Source discussion ↗
“Inositol - 2-4G (500mg pills) anxiolytic”
Source discussion ↗
Top discussions (5)

Other options for anxiety

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate