Tianeptine vs Tianeptine Sulfate for mood
Short answer: For mood, more users report improvement with Tianeptine — 95% of 148 reports, versus 73% of 15 for Tianeptine Sulfate.
Tianeptine has 18 meta-analyses and 42 randomized trials on PubMed; Tianeptine Sulfate has 18 and 42.
Based on 322 reports about Tianeptine and 34 about Tianeptine Sulfate. Not medical advice.
| Tianeptine Medication | Tianeptine Sulfate Medication | |
|---|---|---|
| Users say it helped | 63%helped155 reports · high confidence | 66%helped21 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 18 / 42 | 18 / 42 |
| Mainly used for | ||
| Mood % reporting improvement | 95% (148) | 73% (15) |
| Anxiety % reporting improvement | 95% (62) | 88% (8) |
| Focus % reporting improvement | 93% (14) | — |
| Energy % reporting improvement | 86% (14) | — |
| Common side effects | addiction, withdrawal, tolerance, headache | drowsiness, feeling odd, insomnia, stimulation |
| Typical dose reported | Not listed | Not listed |
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“It has really improved the quality of my life, more than anything else I have taken.”
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“tried Tianeptine Sulfate - my hero was born. From day one, and every day after, I've experienced massive bronchodilation for a notably extended period of time with no noticeable crash whatsoever.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate