Sertraline vs Tianeptine for mood
Short answer: For mood, more users report improvement with Tianeptine — 95% of 148 reports, versus 65% of 54 for Sertraline.
Sertraline has 318 meta-analyses and 906 randomized trials on PubMed; Tianeptine has 18 and 42.
Based on 136 reports about Sertraline and 322 about Tianeptine. Not medical advice.
| Sertraline Medication | Tianeptine Medication | |
|---|---|---|
| Users say it helped | 37%helped86 reports · medium confidence | 63%helped155 reports · high confidence |
| Verdict | Mixed | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 318 / 906 | 18 / 42 |
| Mainly used for | ||
| Mood % reporting improvement | 65% (54) | 95% (148) |
| Anxiety % reporting improvement | 86% (37) | 95% (62) |
| Energy % reporting improvement | 33% (9) | 86% (14) |
| Focus % reporting improvement | 57% (7) | 93% (14) |
| Libido % reporting improvement | 10% (10) | — |
| Common side effects | fatigue, numbness, brain fog, sexual dysfunction | addiction, withdrawal, tolerance, headache |
| Typical dose reported | Not listed | Not listed |
All antidepressants were more efficacious than placebo in adults with major depressive disorder. Smaller differences between active drugs were found when placebo-controlled trials were included in the analysis, whereas there was more variability in efficacy and acceptability in head-to-head trials. These results should serve evidence-based practice and inform patients, physicians, guideline developers, and policy makers on the relative merits of the different antidepressants.
Lancet, 2018 ↗“The first 2 months were amazing. No thinking before every word. I just reacted, talked, did things. Pleasure. I could enjoy games, sunrises, weather. Anxiety gone. Woke up with energy no exhaustion.”
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“It has really improved the quality of my life, more than anything else I have taken.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate