Tianeptine vs Tramadol for mood
Short answer: For mood, more users report improvement with Tramadol — 100% of 4 reports, versus 95% of 148 for Tianeptine.
Tianeptine has 18 meta-analyses and 42 randomized trials on PubMed; Tramadol has 270 and 1,371.
Based on 322 reports about Tianeptine and 15 about Tramadol. Not medical advice.
| Tianeptine Medication | Tramadol Medication | |
|---|---|---|
| Users say it helped | 63%helped155 reports · high confidence | 50%helped10 reports · few reports |
| Verdict | Mostly positive | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 18 / 42 | 270 / 1,371 |
| Mainly used for | ||
| Mood % reporting improvement | 95% (148) | 100% (4) |
| Anxiety % reporting improvement | 95% (62) | 100% (2) |
| Energy % reporting improvement | 86% (14) | 67% (3) |
| Focus % reporting improvement | 93% (14) | 100% (2) |
| Common side effects | addiction, withdrawal, tolerance, headache | addiction risk, tolerance, dangerous, habit-forming, nausea |
| Typical dose reported | Not listed | Not listed |
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“It has really improved the quality of my life, more than anything else I have taken.”
Our results support a revision of the NeuPSIG recommendations for the pharmacotherapy of neuropathic pain. Inadequate response to drug treatments constitutes a substantial unmet need in patients with neuropathic pain. Modest efficacy, large placebo responses, heterogeneous diagnostic criteria, and poor phenotypic profiling probably account for moderate trial outcomes and should be taken into account in future studies.
Lancet Neurol, 2015 ↗“I had this when my dentist gave me tramadol...My work day just felt easier, I had a basic level of attention and caring for things.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate