Saffron vs Tianeptine for mood
Short answer: For mood, users rate them about the same: 92% report improvement with Saffron (165 reports) and 95% with Tianeptine (148 reports).
Saffron has 88 meta-analyses and 119 randomized trials on PubMed; Tianeptine has 18 and 42.
Based on 421 reports about Saffron and 322 about Tianeptine. Not medical advice.
| Saffron Supplement | Tianeptine Medication | |
|---|---|---|
| Users say it helped | 62%helped223 reports · high confidence | 63%helped155 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 88 / 119 | 18 / 42 |
| Mainly used for | ||
| Mood % reporting improvement | 92% (165) | 95% (148) |
| Anxiety % reporting improvement | 81% (84) | 95% (62) |
| Focus % reporting improvement | 79% (38) | 93% (14) |
| Energy % reporting improvement | 81% (21) | 86% (14) |
| Sleep % reporting improvement | 72% (18) | 75% (4) |
| Common side effects | headache, appetite suppression, insomnia, vivid dreams | addiction, withdrawal, tolerance, headache |
| Typical dose reported | 30 mg | Not listed |
Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested.
J Atten Disord, 2024 ↗“I just sneak some into whatever soup we are having. I honestly think it has made a huge difference.”
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“It has really improved the quality of my life, more than anything else I have taken.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate