Bupropion vs Tianeptine for mood
Short answer: For mood, more users report improvement with Tianeptine — 95% of 148 reports, versus 70% of 172 for Bupropion.
Bupropion has 411 meta-analyses and 617 randomized trials on PubMed; Tianeptine has 18 and 42.
Based on 444 reports about Bupropion and 322 about Tianeptine. Not medical advice.
| Bupropion Medication | Tianeptine Medication | |
|---|---|---|
| Users say it helped | 41%helped271 reports · high confidence | 63%helped155 reports · high confidence |
| Verdict | Mixed | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 411 / 617 | 18 / 42 |
| Mainly used for | ||
| Mood % reporting improvement | 70% (172) | 95% (148) |
| Anxiety % reporting improvement | 15% (34) | 95% (62) |
| Focus % reporting improvement | 71% (62) | 93% (14) |
| Energy % reporting improvement | 81% (57) | 86% (14) |
| Libido % reporting improvement | 76% (34) | — |
| Common side effects | anxiety, insomnia, irritability, tinnitus | addiction, withdrawal, tolerance, headache |
| Typical dose reported | Not listed | Not listed |
Our findings represent the most comprehensive available evidence base to inform patients, families, clinicians, guideline developers, and policymakers on the choice of ADHD medications across age groups. Taking into account both efficacy and safety, evidence from this meta-analysis supports methylphenidate in children and adolescents, and amphetamines in adults, as preferred first-choice medications for the short-term treatment of ADHD. New research should be funded urgently to assess long-term effects of these drugs.
Lancet Psychiatry, 2018 ↗“It really helped. I went from being suicidal to having hope and motivation within 3 days of starting the medication.”
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“It has really improved the quality of my life, more than anything else I have taken.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate