Probiotics vs Tianeptine for mood
Short answer: For mood, more users report improvement with Probiotics — 100% of 54 reports, versus 95% of 148 for Tianeptine.
Probiotics has 2,293 meta-analyses and 2,235 randomized trials on PubMed; Tianeptine has 18 and 42.
Based on 479 reports about Probiotics and 322 about Tianeptine. Not medical advice.
| Probiotics Supplement | Tianeptine Medication | |
|---|---|---|
| Users say it helped | 63%helped144 reports · high confidence | 63%helped155 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 2,293 / 2,235 | 18 / 42 |
| Mainly used for | ||
| Mood % reporting improvement | 100% (54) | 95% (148) |
| Anxiety % reporting improvement | 90% (29) | 95% (62) |
| Digestion % reporting improvement | 84% (86) | — |
| Focus % reporting improvement | 70% (10) | 93% (14) |
| Energy % reporting improvement | 80% (10) | 86% (14) |
| Common side effects | stomach issues, brain fog, diarrhea, withdrawal | addiction, withdrawal, tolerance, headache |
| Typical dose reported | 2 capsules / daily | Not listed |
Some combinations of probiotics or strains may be beneficial in IBS. However, certainty in the evidence for efficacy by GRADE criteria was low to very low across almost all of our analyses.
Gastroenterology, 2023 ↗“What finally made a difference was taking probiotics...I felt better fairly quickly.”
Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Mol Psychiatry, 2023 ↗“It has really improved the quality of my life, more than anything else I have taken.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate